Experts remind that overuse of drugs can easily lead to this disease... College students who take medication indiscriminately for colds and their urine turns sour and oily
A college student took medication for a cold and suffered from acute kidney injury. Fortunately, after being treated at Zhongshan Hospital affiliated with Fudan University, he was able to recover and be discharged smoothly. Medical experts remind that when taking cold medicine, it is important not to overdo it. It is important to drink plenty of water and rest regularly. If you experience lower back pain, lower back pain, or reduced urine output, it is important to seek medical attention promptly from a nephrologist.
During Xiao Wei's summer internship at school, he suddenly had a fever, with a temperature of 39.5 ° C. He took the compound aminophenamine according to the medication instructions for 3 days, but the fever still persisted. He also took cold medicine containing acetaminophen, and then began to experience lower back pain, lower limb pain, and urine turned oily!
According to the emergency examination at Zhongshan Hospital, Xiaowei is diagnosed with acute kidney injury, liver failure, rhabdomyolysis, pulmonary infection, and heart failure. The condition is severe, and if not treated in time, it will be life-threatening. The patient was immediately admitted to the nephrology department, and blood creatinine continued to rise to 1285 μ Mol/L, accompanied by anuria.
Under the guidance of Director Ding Xiaoqiang from the Department of Nephrology, the treatment team provided hydration, alkalization of urine, and anti infection treatment to patients. At the same time, the CRRT team from the Department of Nephrology actively cooperated and performed bedside blood dialysis.
Fortunately, the treatment was timely, and the patient's liver function began to improve, with muscle enzyme indicators gradually decreasing. However, renal function remained poor, and renal biopsy was needed as soon as possible. After fully evaluating the risks, Deputy Chief Physician Xu Xialian completed a renal puncture. The pathological report showed "acute tubular necrosis with myoglobin tubular formation", indicating that renal function is expected to recover.
The nephrology team adjusts the treatment plan based on pathology. Two weeks later, Xiao Wei's urine output finally returned to normal, and his blood creatinine slowly dropped to 144 μ Mol/L. Acute kidney failure caused by cold medicine has finally come to an end after 39 days of treatment.
Why does taking cold medicine cause kidney damage? Expert explanation: This is not an isolated case, the culprit is acetaminophen in cold medicine. Data shows that 9% of patients who overdose or take it for a long time may experience acute kidney injury or chronic kidney disease. The toxic metabolites produced by acetaminophen can cause damage to renal tubular epithelial cells, with acute tubular necrosis being the main pathological manifestation.
This time, Xiaowei's renal dysfunction started rapidly and progressed to renal failure in the short term, leading to acute tubular necrosis, which is also the most common type of acute kidney injury. Excessive sweating leads to an increase in drug concentration, while fever, infection, and rhabdomyolysis further exacerbate the condition.
Generally speaking, acute tubular necrosis is mostly reversible, and as long as treated promptly, renal function can be fully restored within weeks or months. It is worth noting that acetaminophen can also cause acute interstitial nephritis, which is completely different from the treatment of acute tubular necrosis. Therefore, when acute kidney injury related to cold medicine occurs, renal puncture biopsy should be performed as soon as possible to clarify the pathology, timely and correct treatment, and buy valuable time for the recovery of the disease.
