"Cell" magazine publishes the major research results of Qu Jieming and other collaborative teams from Ruijin Hospital
On September 27, the collaborative team of Professor Qu Jieming, Professor Zhu Jiang, Professor Li Qingyun and Academician Chen Saijuan of Ruijin Hospital, Shanghai Jiao Tong University School of Medicine published a research paper in Cell magazine, which for the first time systematically described the effect of inactivated COVID-19 vaccination on Omicron infection. The impact of the patient's immune response reveals the molecular mechanism by which the three-time booster inactivated vaccine promotes the activation and maturation of monocytes by inducing "trained natural immunity", thereby exerting a powerful antiviral effect.
As of September 21, 2023, the global new coronavirus SARS-CoV-2 pandemic has resulted in more than 770 million confirmed cases and more than 6.95 million deaths in more than 200 countries and regions, seriously threatening human health and public health security. Widespread epidemics continue to occur as the new coronavirus evolves and mutates.
It is generally believed that vaccination plays a role in preventing viral infection and virus transmission by establishing specific antiviral immune memory for the host in advance. However, the immune protective effect and immunological mechanism of the new coronavirus mRNA vaccine or/and inactivated vaccine are still unclear. Previous studies have focused on the establishment of specific humoral immunity and cellular immune memory against Omicron variants triggered by the new coronavirus mRNA vaccine or inactivated virus vaccine. Whether the antiviral effect of inactivated vaccination involves the induction of "natural immune memory", so far So far it's unclear.
In this context, the research team such as Qu Jieming from Ruijin Hospital took the outbreak of Omicron mutant strains in Shanghai in the spring of 2022 as the research object, and established a research cohort composed of infected and uninfected people who had received different times of inactivated virus vaccines. By integrating mass spectrometry flow Olink detection technology and integrated analysis of transcriptome sequencing and plasma trace proteins revealed that vaccination with three booster vaccines promotes the activation of HLA-DRhigh classical monocytes and non-classical monocytes, Th1-like memory effector T It exerts immunoprotective effects by polarizing cells and inhibiting the expansion of pathological regulatory T cells. Correlation analysis and other studies suggest that vaccination with three booster vaccines induces "trained natural immunity", which promotes the activation and maturation of monocytes during Omicron infection instead of differentiating into myeloid-derived suppressor cells. It is a triggering system. A core event in the protective immune effect. This study is the first to systematically describe the impact of inactivated COVID-19 vaccination on the immune response of Omicron-infected patients, revealing that three booster inactivated vaccines promote the activation and maturation of monocytes by inducing "training innate immunity" , thereby exerting a molecular mechanism of powerful antiviral effect.
Professor Qu Jieming from the Department of Respiratory and Critical Care Medicine of Ruijin Hospital, Professor Zhu Jiang from the Shanghai Institute of Hematology, Professor Li Qingyun from the Department of Respiratory and Critical Care Medicine, and Academician Chen Saijuan from the National Major Science and Technology Infrastructure for Translational Medicine are the co-corresponding authors of the paper. Yu Shanhe, associate researcher at the National Major Science and Technology Infrastructure in Translational Medicine, Lin Yingni, the attending physician, and Li Yong, the deputy chief physician of the Department of Respiratory and Critical Care Medicine, Chen Shijun, a doctoral candidate at the Shanghai Institute of Blood Research, Zhou Lina, the attending physician, and Song Hejie, the technician of the Department of Respiratory and Critical Care Medicine, contributed to the paper. co-author.
