Returning to a "good" head shape, even slapping the forehead? 3D printing shows a male baby's skull reassembled, with a 1-year-old baby's head resembling a boat shaped eye socket | Child | Skull

Release time:Apr 13, 2024 21:51 PM

At the full moon, Xiaoqingqing was discovered to have a protruding frontal bone and some abnormal head shape, but the family didn't pay much attention and always thought it would be better if it grew longer. However, as Qingqing grew up, his mother found that he had neither a round head nor a flat head, but a boat shaped head; Xiao Qingqing's temper gradually became irritable, often crying and even slapping her forehead. Wang Xiaoqiang, Deputy Director of Pediatric Neurosurgery at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, found that behind the head of the boat is a condition of cranial stenosis, which not only affects appearance, but may also lead to brain dysfunction.

In order to minimize the impact on children, Wang Xiaoqiang re customized Qingqing's skull by 3D printing and reshaping it, and through surgical stitching, helped Qingqing restore a circular head.

The child's head shape is becoming increasingly strange, it turns out to be narrow skull syndrome

When the parents of the post-90s generation rushed from Jiangsu to Xinhua Hospital with their 1-year-old Qingqing in their arms, they looked worried. The child's mother told Wang Xiaoqiang that when Qingqing was full moon, she first noticed a protruding frontal bone and abnormal head shape. At that time, she did not pay attention, but as the child grew older, the situation not only did not improve, but also became more apparent. This couple has traveled to various local hospitals with their children and met countless doctors, but the conclusion is: follow-up observation.

Observing day and night has made parents increasingly worried: "When Qingqing is 10 months old, the head CT shows a slight depression at the junction of the frontal and temporal bones on both sides; at 11 months old, a follow-up examination reveals that the child's forehead is narrow and pointed, and the anterior fontanelle is basically closed. It is recommended to continue follow-up observation." Taking into account the child's medical history and preliminary examination results, Wang Xiaoqiang believes that the child not only has an unsightly head shape, but also has a narrow skull syndrome.

Skull stenosis, also known as early closure of cranial sutures or cranial bone stenosis, is a collective term for diseases such as narrowing and deformities of the cranial cavity caused by one or more cranial sutures being closed prematurely in infants and young children, as well as restricted brain development.

But this disease is not uncommon. On a global scale, one out of every 2000 to 2500 babies is born, ranking second in congenital craniofacial malformations, second only to cleft lip and palate. Male patients are more common than females, accounting for 60% to 80% of the total number of patients.

So, why does Qingqing suffer from craniostenosis? Faced with his mother's question, Wang Xiaoqiang introduced that the cause of the disease is currently unknown, but some of it is related to genetic mutations. Premature closure of cranial sutures during a child's growth and development can lead to a narrow cranial cavity that cannot adapt to normal brain development. It can manifest as various head deformities, such as boat shaped head, triangular head, oblique head, pointed head, etc; It can also manifest as elevated intracranial pressure, developmental delay, low intelligence, abnormal mental activity, seizures, and other symptoms.


Returning to a "good" head shape, even slapping the forehead? 3D printing shows a male baby's skull reassembled, with a 1-year-old baby's head resembling a boat shaped eye socket | Child | Skull

After 3D reconstruction of the head CT, the unloading of the orbit and reconstruction return to a "good" head shape

After admitting Qingqing to the hospital, Wang Xiaoqiang had multiple communications and exchanges with Director Ma Jie of the Pediatric Neurosurgery Department, brainstorming and jointly discussing the surgical plan to ensure good surgical results. The primary goal of cranial stenosis surgery is to relieve intracranial hypertension, followed by the restoration of the skull prototype. Experts immediately developed the most suitable surgical treatment plan for children through head CT three-dimensional reconstruction and head MRI examination.

Wang Xiaoqiang performed 3D printing and reshaping of the skull based on the imaging data of the patient before surgery, obtaining a 1:1 resin model. The surgery was simulated first. During the simulation operation, it was found that the eye sockets of the patient were shorter and narrower than those of normal children. If only routine operations were performed, although intracranial pressure was released, it could not solve the problem of the eye sockets. From the perspective of postoperative beauty, the effect could not be optimal. However, to solve the problem of the eye socket, it is necessary to remove the socket and then reassemble it, which will consume more time and energy compared to conventional surgical procedures. Considering the future of the child, Wang Xiaoqiang decided to take an even more difficult path - to break free and reorganize.

During the surgery, doctors found that the intracranial pressure in the child had reached 19cmH2O, which is also an important factor for the child's tendency to cry. After opening the skull, it was found that the child's bones had multiple indentations and some of the bones were thin, further confirming the child's cranial hypertension. The entire surgery lasted for 5 hours. The doctors removed the entire skull above the eye socket of the patient, and went through a series of processes such as osteotomy, suturing, rotation, replacement, splicing, expansion, shaping, and fixation. The effect was immediate, and the patient's deformed boat shaped head turned into a normal round head, restoring its smart and lovely appearance. On the second day after the surgery, Qingqing's condition stabilized and he was transferred to a regular ward, and he was no longer prone to crying.

Wang Xiaoqiang pointed out that there is currently no special drug treatment for craniostenosis, and only surgical methods can be used. The purpose is to expand the cranial cavity, relieve intracranial pressure, enable normal development of brain tissue, protect vision, and also improve appearance. For cranial stenosis, early detection and treatment are necessary. Different age groups have different treatment options, such as minimally invasive neuroendoscopic craniotomy, skull traction, and skull reconstruction. The treatment of craniostenosis should combine the characteristics of pediatric neurosurgery and plastic surgery, and adopt individualized treatment to improve the child's appearance and restore cranial function.

Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer
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Immunotherapy has been proven to achieve significant therapeutic effects in various solid tumors. However, for pancreatic cancer, known as the "king of cancer", immunotherapy has been ineffective. On August 4, Professor Yu Xianjun, Dean of the Cancer Hospital Affiliated to Fudan University, and Shi Si, Associate Professor of Pancreatic Surgery released a research achievement, which first found the key role of cysteine rich protein 1 in shaping the immunosuppressive microenvironment of pancreatic cancer, filled the gap in the research field of immunosuppressive microenvironment of pancreatic cancer, and provided a theoretical basis for precise immunotherapy of pancreatic cancer patients. Ductal adenocarcinoma of the pancreas is the main type of pancreatic cancer, accounting for about 90% of all pancreatic cancer. Due to its high malignancy and poor treatment effectiveness, pancreatic ductal adenocarcinoma has always been one of the most malignant tumors. In recent years, the level of surgical techniques and comprehensive treatment has been achieved

A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare
A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare

A 14-year-old girl has been experiencing symptoms such as protruding pupils, incomplete eye closure, corneal injury, restricted eye movement, and overall fatigue for several years. The physical discomfort and facial abnormalities caused by eye diseases have made her increasingly reticent, and her temperament is vastly different from before. At the Ophthalmology Department of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the pupil has been diagnosed with a rare thyroid ophthalmopathy combined with myasthenia gravis, which requires prompt treatment. However, considering the young age of the pupil, conventional hormone and radiation therapy cannot be used. Therefore, Zhou Huifang, Deputy Director of Ophthalmology and thyroid ophthalmology expert, has developed a targeted drug combined with surgical treatment plan for it, and targeted drug treatment will be performed first. Three months ago, I was hospitalized for one week with mydriasis and received intravenous targeted drug treatment. Afterwards, I went home for observation and followed up on time

The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease
The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease

According to the Statistics of Chinese Dry Eye Expert Consensus, the incidence rate of dry eye in China is about 21%~30%, and it is estimated that there are at least 300 million patients nationwide. The Dry Eye Diagnosis and Treatment Studio of Shanghai Eye Disease Prevention and Treatment Center was officially launched today. In the future, the studio will continuously improve the dry eye diagnosis and treatment standards, and form standardized diagnosis and treatment concepts and service models. Suitable technologies will be promoted to the community, allowing residents to enjoy convenient dry eye diagnosis and treatment services at their doorstep. Executive Dean and Party Secretary Gao Wei stated that this is also one of the livelihood service measures recently launched by the hospital around high-quality development and meeting the needs of the people. It is reported that dry eye syndrome is a chronic ocular surface disease caused by multiple factors. The instability of the tear film or imbalance of the ocular surface microenvironment caused by abnormal quality, quantity, and dynamics of tears can be accompanied by ocular surface inflammatory reactions, tissue damage, and nerve abnormalities, resulting in various discomforts in the eyes

The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice
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The International Dental Implant Consensus Report, jointly written by the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine and renowned universities in the field of dentistry such as Harvard University, University of Zurich, University of Gothenburg, Columbia University, and University of Frankfurt, has recently been jointly published in top journals in the field of dentistry, including Clinical Periodontology and Clinical Dental Implant Research. This consensus has for the first time established an internationally unified core set of indicators for evaluating the clinical effectiveness of dental implants, covering the five key areas of the field of dental implants. It is of milestone significance for carrying out standardized clinical diagnosis, treatment, and research on dental implants. The core evaluation indicators determined by this consensus will become an important benchmark for scholars in the field of dental implants worldwide to conduct high-quality research. The consensus is composed of 8 top international experts in the field of oral implantation

Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases
Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases

Recently, Catherine, a British girl born in the 1990s, received autologous peripheral blood hematopoietic stem cell transfusion at the Cancer Center of Shanghai Jiahui International Hospital, and was successfully discharged from the warehouse. She is now on her way back to China after being discharged from the hospital. She is also the first patient at Shanghai Jiahui International Hospital to complete relevant treatments. In 2019, Catherine was diagnosed with Hodgkin's lymphoma in the UK, and after treatment, the disease completely improved. During her work and life in China in 2021, she went to seek medical attention due to multiple enlarged lymph nodes. Pathological biopsy confirmed a recurrence of Hodgkin's lymphoma, and through combined targeted drug treatment, her condition was temporarily under control. Last year in the second half of the year, when the disease recurred, the girl began to use immunotherapy combined with targeted drugs for treatment. Expert evaluation suggests that for young patients with hematological tumors, the risk of recurrence is high and treatment difficulty is increasing in the future. Autologous hematopoietic stem cell therapy is recommended