For the first time, the New England Journal of Medicine published two results of Chinese scholars at the same time: a major breakthrough in the research of Zhou Caicun's team

Release time:Apr 24, 2024 00:18 AM

The 2023 ESMO Annual Meeting hosted by the European Society of Medical Oncology will kick off on October 20, 2023 in Madrid, Spain. On the evening of October 21, cancer research led by Chinese scholars ushered in a historic moment - two international multi-center phase III clinical trials, the LIBRETTO-431 study and the PAPILLON study, led by Professor Zhou Caicun from the Shanghai Pulmonary Hospital Affiliated to Tongji University, were unveiled simultaneously. , two research papers were also published in the New England Journal of Medicine at the same time, with Zhou Caicun ranked as the first author and corresponding author. This is the first time in the field of Chinese cancer research that the same Chinese scholar has published the results of two international multi-center clinical studies in the same journal of NEJM as the first and corresponding author, conveying China's voice and giving Chinese solutions on the highest stage of world medicine.

Results of two international multi-center phase III trials: The PAPILLON study proved that the "evantumumab chemotherapy" regimen can significantly extend the median progression-free survival of advanced non-small cell lung cancer carrying epidermal growth factor receptor exon 20 insertion mutations ; In another phase III LIBRETTO-431 trial that included RET fusion-positive non-small cell lung cancer, seputinib improved the median progression-free survival compared with "platinum-based chemotherapy ± pembrolizumab" More than doubled. These two studies further confirm that timely, comprehensive genomic testing will provide an important basis for initial treatment decisions for all patients with non-small cell lung cancer.

For a long time, there is usually a lack of effective treatment strategies for some rare types of lung cancer. These two studies provide new treatment options for such patients, giving patients more and better treatment options and possibilities. The main manifestations are: first, improving the treatment effect. The first-line treatment strategy for rare targets is expected to make the treatment of these patients more precise and effective, allowing patients to achieve better recovery and quality of life; second, it saves medical resources. Medical resources can be used more effectively and unnecessary examinations and treatments can be avoided for patients who do not require specific treatment; the third is to promote the advancement of medical technology. The identification of rare target treatment strategies can promote progress in the field of clinical basic translation and bring better treatment options to patients; fourth, it provides reference and inspiration. The successful application of rare target treatment strategies can provide reference and inspiration for the treatment of other similar diseases.

"Although advanced non-small cell lung cancer usually requires immediate start of treatment after diagnosis, the results of the two studies further demonstrate the importance of incorporating biomarker testing into the routine diagnosis and treatment process to guide clinical decisions at an early stage and develop the most effective treatment plan." Under the leadership of Zhou Caicun, the oncology team of the Pulmonary Hospital took the lead in discovering lung cancer treatment targets and clinical translation research. The early diagnosis rate of lung cancer increased from 69% to 95%. Molecular testing helped 95% of late-stage lung cancer patients find driver genes. More and more patients are getting a chance of long-term survival under the guidance of hospital treatment plans. In the field of global oncology, the team has established a comprehensive, accurate and fast precision diagnosis and treatment system for lung cancer. From the first diagnosis to the initial establishment of a treatment plan for a patient, it only takes 4 working days, achieving the "China speed" of lung cancer diagnosis and treatment.

"Clinical research is the only way for the high-quality development of the hospital. It is the core link that connects basic research and clinical application and realizes medical technological innovation." Chen Chang, Secretary of the Party Committee of the Pulmonary Hospital, said that the hospital will further introduce new and original basic and clinical research in " Under the concept of "patient-centered, clinical frontline-centered", we focus on the difficulties, pain points, and blockages in people's medical treatment.


For the first time, the New England Journal of Medicine published two results of Chinese scholars at the same time: a major breakthrough in the research of Zhou Caicun's team
Shanghai doctors visit Wannan Farm to provide health care to retired elderly people
Shanghai doctors visit Wannan Farm to provide health care to retired elderly people

On the Double Ninth Festival, we express our sincere respect for the elderly. Recently, the Shanghai Elderly Foundation, Guangzheng New Vision Eye Hospital Group, and Guangming Food Co., Ltd. joined hands with the "Wannan Farm Charity Tour" to visit Baimaoling Farm and Juntian Lake Farm to provide free medical services to local retired elderly people, and at the same time send them cold-warming and Nursing products, warm the body and mind of the elderly through acts of kindness. In the square of Juntian Lake Farm Community Service Center in the early morning of autumn, retired elderly people lined up early in the morning, waiting for inspection. Medical staff have set up free clinics here to conduct detailed examinations for the elderly, answer questions on-site about common eye diseases such as cataracts, glaucoma, dry eye, and pterygium, and provide precautions for patients who need treatment. On the same day, elderly people with dry eye symptoms also experienced a dry eye mist fumigation project. “The biggest worry for us seniors is that it’s difficult to see a doctor. Doctors and nurses work tirelessly to come to our homes for free clinics.

"I hope he can enjoy the sunshine and beauty in the distance!" On the same day in Shanghai, three handsome young men donated hematopoietic stem cells.
"I hope he can enjoy the sunshine and beauty in the distance!" On the same day in Shanghai, three handsome young men donated hematopoietic stem cells.

On the same day in Shanghai, three handsome young men donated hematopoietic stem cells. They worked in different jobs and had very different personalities, but they all had the same wish - to pass on the seeds of life, donate hematopoietic stem cells and pass on the hope of life. According to the Shanghai Red Cross, this is also the first time that three donations have been completed on the same day in Shanghai, and the Shanghai Red Cross has exceeded 600 hematopoietic stem cell donations at the same time. As of early October 2023, the China Bone Marrow Bank has a cumulative storage capacity of 3.28 million people, and has provided human leukocyte antigen matching retrieval services to more than 117,000 hematological disease patients, and more than 16,000 unrelated hematopoietic stem cell donations. The Shanghai branch of the China Marrow Bank has a total of more than 170,000 volunteers from all walks of life, always ready to send the seeds of life to patients with blood diseases. "Marrow edge" is waiting, be a simple and good person

A 7-year-old boy who appears to have a "chicken chest" actually hides a huge tumor! Xinhua experts complete a 5-hour bomb disposal surgery | Tumor | Xinhua
A 7-year-old boy who appears to have a "chicken chest" actually hides a huge tumor! Xinhua experts complete a 5-hour bomb disposal surgery | Tumor | Xinhua

A 7-year-old boy named Lele had a protruding chest and mistakenly thought it was a "chicken chest", but in reality, he concealed a huge tumor that occupied half of his chest, like a "bomb", close to the heart and large blood vessels, posing a life-threatening danger at any time. Lu Yanan, the director of the Pediatric Heart Center at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, skillfully removed a tumor weighing up to 1 kilogram in just 5 hours. Xiao Lele has recently recovered and been discharged from the hospital. The boy's "chicken chest" turned out to be a huge tumor. Not long ago, Lele's parents found that his chest had obvious protrusions and sought medical attention locally. The doctor initially suspected it to be a "chicken chest" and could continue to observe or wait for surgery. However, they still have some doubts in their hearts, why are children always so thin that they can't gain weight no matter how they eat? So they continued to seek medical attention with Lele, and a CT scan revealed that,

How to diagnose the "killer" of sudden death in young people? Zhongshan Hospital first proposed the results of "Gene Echocardiography" in an authoritative journal titled "Hypertrophic Type | Echocardiography Room | Gene"
How to diagnose the "killer" of sudden death in young people? Zhongshan Hospital first proposed the results of "Gene Echocardiography" in an authoritative journal titled "Hypertrophic Type | Echocardiography Room | Gene"

The silent killer hidden behind the sudden collapse of young people is likely hereditary hypertrophic cardiomyopathy, which is one of the most common causes of sudden death in young people. How to accurately diagnose this disease and save more young lives? Recently, Professor Shu Xianhong's team from the Ultrasound Department of Zhongshan Hospital affiliated with Fudan University published their research findings in the international authoritative academic journal of cardiovascular disease, the Cardiovascular Imaging Sub Journal of the European Journal of Cardiology, stating that genetic echocardiography significantly improves the diagnostic efficiency of hereditary hypertrophic cardiomyopathy. The team first proposed the concept of "gene cardiac ultrasound" internationally, innovatively drawing a gene cardiac ultrasound map of hypertrophic cardiomyopathy. This plan will significantly improve the accuracy and efficiency of diagnosis. It is reported that hypertrophic cardiomyopathy is the most common inherited heart disease and also the most complex type of disease. This disease is the main cause of sudden death in young people

First, become a "patient": Dongfang Hospital's "Outpatient Service Experience Officer" has been launched, aiming to become a doctor, patient, hospital, and outpatient
First, become a "patient": Dongfang Hospital's "Outpatient Service Experience Officer" has been launched, aiming to become a doctor, patient, hospital, and outpatient

At 9 a.m. on July 26, five young people in the outpatient hall of the North Hospital of Shanghai Oriental Hospital put on volunteer "blue vests". Unlike other volunteers in the hospital, their other identity is the hospital's digestive endoscopy center. After work, he joined the hospital volunteer team and played a special role-as an "outpatient service experience officer" to conduct hospital service satisfaction surveys. This creative setting is one of the projects in the special work of Oriental Hospital to improve its service throughout the year. In the hot summer, the hospital through a number of intentional initiatives to help re-optimize the diagnosis and treatment services. To be a doctor, first learn to be a "patient" clinic is the first "window" of hospital medical work ". In May this year, the National Health Commission and the State Administration of Traditional Chinese Medicine jointly issued the theme of "Improving Medical Experience and Enhancing Patient Experience".