Focus on the cutting-edge international biomedicine track: Type 2 diabetes living biopharmaceutical pipeline officially launched in Zhangjiang Pharmaceutical Valley

Release time:Apr 23, 2024 22:16 PM

On October 8, under the witness of the Shanghai Modern Service Industry Federation’s General Health Professional Committee, the Zhangjiang Live Biopharmaceutical Research and Development Center’s Type 2 Diabetes Live Biopharmaceutical Pipeline was officially launched. Jian Danian, vice president of Shanghai Modern Service Industry Federation, said that the Federation will continue to closely follow Shanghai's modern industrial system and introduce more high-level technology enterprises to Pudong and Zhangjiang.

This is the earliest comprehensive national science center established. Over the past 30 years, 24,000 companies, more than 1,800 high-tech enterprises, and 179 foreign-funded R&D centers have "emerged" on the fertile soil of Zhangjiang Science City. At present, it has a series of national strategic overlay opportunities such as the National Science and Technology Innovation Center, Independent Innovation Demonstration Zone, Shanghai Pilot Free Trade Zone, Pudong Leading Zone, and High-level Talent Highlands.

Why does Zhangjiang focus on diabetes drug pipeline this time? What else can the biomedical industry do in Zhangjiang? Experts are hotly discussing new drug research and development and entrepreneurial ecology.

Create a “tropical rainforest” venture capital ecosystem in Zhangjiang

It is reported that the Zhangjiang Medicine Valley Platform was established in 2004. At the end of 2007, it was certified as the "National High-tech Entrepreneurship Service Center" by the Ministry of Science and Technology, and was accredited by the National Conformity Assessment Laboratory. Zhangjiang Medicine Valley relies on incubation services, with professional technical services and investment and financing services as its pillars, focusing on professional incubation and cultivation at the front end of the new drug R&D and production chain. "For more than 30 years, Zhangjiang, located in Pudong New Area, has long been the first choice for entrepreneurial students returning from overseas." Yuan Tao, chairman of Shanghai Group Co., Ltd., said that firstly, Shanghai itself is an international city; secondly, Zhangjiang has a large number of multinational companies Companies and R&D centers, with spillover effects superimposed on industrial development, naturally form an entrepreneurial ecosystem. Especially in recent years, the country has attached great importance to high-tech development, and biomedicine, artificial intelligence and integrated circuits have become Shanghai's three core industries. “Especially in the field of biomedicine, Zhangjiang is providing opportunities for small, medium and micro enterprises.

Ling Gang, chief engineer of the Pudong New Area Science and Economic Commission, said that real Chinese drug innovation began in about 2014 and has entered an acceleration period in the past ten years. "Currently, the number of innovative drugs in my country accounts for about 23.7% of the world's total. From a short-term perspective, there is no doubt that it belongs to the second largest echelon in the world." According to reports, taking Zhangjiang as an example, it focuses on drug research and development in the fields of cells, genes and other fields. , will strive to create a "tropical rainforest-style" venture capital ecosystem in terms of industry positioning, policy support, and service platforms.

He vividly likened it to the "six major canal industries" - by 2025, Pudong will cultivate six hard-core industrial clusters with a scale of "100 billion yuan", among which "innovative drugs" will be built into a 200 billion yuan industrial cluster. "In the next step, we will invest more support in areas such as talent policy and the development of the traditional Chinese medicine industry."

Ge Guangbo, executive vice president of the Institute of Interdisciplinary Sciences and Chief Pharmacy Consultant of Shanghai University of Chinese Medicine, mentioned that many ingredients in traditional Chinese medicinal materials are difficult to absorb into the blood. Therefore, in many cases, their clinical efficacy is achieved by regulating intestinal flora. Produce endogenous metabolism to achieve improvement. "This is a very promising direction. With the focus of multiple teams from universities, enterprises and medical institutions, we hope that through the close integration of industry, academia and research, basic research will eventually move into clinical practice and develop safe and effective new Chinese drugs."

Create a long-term pipeline platform for intestinal microbiome

The research and development of living biological drugs for type 2 diabetes launched this time is a new attempt by Zhangjiang Enterprises. Chen Weijie, chairman of Shanghai Lishan Biopharmaceutical Co., Ltd., said that based on the latest progress of the research team, a living biological drug targeting intestinal bacteria targeting the insulin resistance subtype of type 2 diabetes will be launched, and is planned to enter Phase 1 clinical trials in 2025. It is reported that this innovative living biological drug is expected to become the first-line drug for specific subgroups of type 2 diabetes and change the current sugar control route of type 2 diabetes. At the same time, more than 700 strains of bacteria with drug-specific characteristics will be screened and isolated by 2026, and the genetic puzzle and culture storage of new strains will be completed.

It is reported that intestinal microbiomics is a new track in international biomedical research. It breaks through the limitations of traditional biomedicine. Through deep learning of big data through cross-multiomics and artificial intelligence, it explores in multi-disciplinary integration. The boundaries of innovative biopharmaceuticals. “Especially in the treatment of inflammatory bowel disease, infections and metabolic diseases, live bacterial therapy has opened up a new revolution in treatment. This therapy neutralizes the inflammation and inflammation caused by pathogens by introducing beneficial microorganisms into the human flora affected by the disease. "Metabolic signals." He revealed that although the project is currently called a pipeline for type 2 diabetes, in the future, it will use this platform to enrich the bacterial library and basic research theories, and expect to eventually generate energy sources for various immune regulation disorders. New drugs.

"The Special Committee on Big Health will be built into a platform that serves enterprises, institutions, members and society, connecting the upstream and downstream industries in the field of big health, providing support for cross-border integration, and allowing more such results to truly take root." Big Health Fan Jincheng, chairman of the special committee, said.

Focus on the cutting-edge international biomedicine track: Type 2 diabetes living biopharmaceutical pipeline officially launched in Zhangjiang Pharmaceutical Valley

Shanghai doctors visit Wannan Farm to provide health care to retired elderly people

On the Double Ninth Festival, we express our sincere respect for the elderly. Recently, the Shanghai Elderly Foundation, Guangzheng New Vision Eye Hospital Group, and Guangming Food Co., Ltd. joined hands with the "Wannan Farm Charity Tour" to visit Baimaoling Farm and Juntian Lake Farm to provide free medical services to local retired elderly people, and at the same time send them cold-warming and Nursing products, warm the body and mind of the elderly through acts of kindness. In the square of Juntian Lake Farm Community Service Center in the early morning of autumn, retired elderly people lined up early in the morning, waiting for inspection. Medical staff have set up free clinics here to conduct detailed examinations for the elderly, answer questions on-site about common eye diseases such as cataracts, glaucoma, dry eye, and pterygium, and provide precautions for patients who need treatment. On the same day, elderly people with dry eye symptoms also experienced a dry eye mist fumigation project. “The biggest worry for us seniors is that it’s difficult to see a doctor. Doctors and nurses work tirelessly to come to our homes for free clinics.

"I hope he can enjoy the sunshine and beauty in the distance!" On the same day in Shanghai, three handsome young men donated hematopoietic stem cells.

On the same day in Shanghai, three handsome young men donated hematopoietic stem cells. They worked in different jobs and had very different personalities, but they all had the same wish - to pass on the seeds of life, donate hematopoietic stem cells and pass on the hope of life. According to the Shanghai Red Cross, this is also the first time that three donations have been completed on the same day in Shanghai, and the Shanghai Red Cross has exceeded 600 hematopoietic stem cell donations at the same time. As of early October 2023, the China Bone Marrow Bank has a cumulative storage capacity of 3.28 million people, and has provided human leukocyte antigen matching retrieval services to more than 117,000 hematological disease patients, and more than 16,000 unrelated hematopoietic stem cell donations. The Shanghai branch of the China Marrow Bank has a total of more than 170,000 volunteers from all walks of life, always ready to send the seeds of life to patients with blood diseases. "Marrow edge" is waiting, be a simple and good person

A 7-year-old boy who appears to have a "chicken chest" actually hides a huge tumor! Xinhua experts complete a 5-hour bomb disposal surgery | Tumor | Xinhua

A 7-year-old boy named Lele had a protruding chest and mistakenly thought it was a "chicken chest", but in reality, he concealed a huge tumor that occupied half of his chest, like a "bomb", close to the heart and large blood vessels, posing a life-threatening danger at any time. Lu Yanan, the director of the Pediatric Heart Center at Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, skillfully removed a tumor weighing up to 1 kilogram in just 5 hours. Xiao Lele has recently recovered and been discharged from the hospital. The boy's "chicken chest" turned out to be a huge tumor. Not long ago, Lele's parents found that his chest had obvious protrusions and sought medical attention locally. The doctor initially suspected it to be a "chicken chest" and could continue to observe or wait for surgery. However, they still have some doubts in their hearts, why are children always so thin that they can't gain weight no matter how they eat? So they continued to seek medical attention with Lele, and a CT scan revealed that,

How to diagnose the "killer" of sudden death in young people? Zhongshan Hospital first proposed the results of "Gene Echocardiography" in an authoritative journal titled "Hypertrophic Type | Echocardiography Room | Gene"

The silent killer hidden behind the sudden collapse of young people is likely hereditary hypertrophic cardiomyopathy, which is one of the most common causes of sudden death in young people. How to accurately diagnose this disease and save more young lives? Recently, Professor Shu Xianhong's team from the Ultrasound Department of Zhongshan Hospital affiliated with Fudan University published their research findings in the international authoritative academic journal of cardiovascular disease, the Cardiovascular Imaging Sub Journal of the European Journal of Cardiology, stating that genetic echocardiography significantly improves the diagnostic efficiency of hereditary hypertrophic cardiomyopathy. The team first proposed the concept of "gene cardiac ultrasound" internationally, innovatively drawing a gene cardiac ultrasound map of hypertrophic cardiomyopathy. This plan will significantly improve the accuracy and efficiency of diagnosis. It is reported that hypertrophic cardiomyopathy is the most common inherited heart disease and also the most complex type of disease. This disease is the main cause of sudden death in young people

First, become a "patient": Dongfang Hospital's "Outpatient Service Experience Officer" has been launched, aiming to become a doctor, patient, hospital, and outpatient

At 9 a.m. on July 26, five young people in the outpatient hall of the North Hospital of Shanghai Oriental Hospital put on volunteer "blue vests". Unlike other volunteers in the hospital, their other identity is the hospital's digestive endoscopy center. After work, he joined the hospital volunteer team and played a special role-as an "outpatient service experience officer" to conduct hospital service satisfaction surveys. This creative setting is one of the projects in the special work of Oriental Hospital to improve its service throughout the year. In the hot summer, the hospital through a number of intentional initiatives to help re-optimize the diagnosis and treatment services. To be a doctor, first learn to be a "patient" clinic is the first "window" of hospital medical work ". In May this year, the National Health Commission and the State Administration of Traditional Chinese Medicine jointly issued the theme of "Improving Medical Experience and Enhancing Patient Experience".

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