More than 300000 patients have benefited and have been applied for free in dozens of hospitals. Shanghai Oriental Hepatobiliary Hospital has created a liver cancer diagnostic model. Factors | Liver Cancer | Shanghai Oriental Hepatobiliary Hospital
China is a major country in liver cancer, with about half of the world's cases and deaths caused by liver cancer. Early identification of high-risk populations and early diagnosis of liver cancer are key to improving the overall survival rate of patients.
The reporter learned from the Third Affiliated Hospital of Naval Medical University that a few days ago, Hepatology Digest invited Professor Shen Feng of the hospital to review the development of diagnostic models for abnormal serum prothrombin and hepatitis B related liver cancer, comment on their latest progress, especially the exploration in Chinese people, and look forward to their future clinical application.
It is understood that the ASAP model developed by Shen Feng's team is the first prediction model specifically for Chinese people, which is used to individually assess the risk of liver cancer in patients with chronic hepatitis B. This model is based on data from nearly 3000 cases and has been widely promoted and used for free in dozens of tertiary hospitals in China, benefiting over 300000 patients.
Shen Feng introduced that age and gender are risk factors for liver cancer, and the clinical blood indicators of alpha fetoprotein and abnormal prothrombin reflect the biological characteristics of liver cancer. The team uses big data to screen and identify the above four indicators, and based on this, constructs a model to accurately evaluate the probability of patients suffering from liver cancer. The relevant results were published in the Journal of Laboratory Chemistry in 2019.
The team also extended the application of this model to the diagnosis of chronic hepatitis C related liver cancer and non-alcoholic fatty liver related liver cancer, with satisfactory diagnostic performance.
At present, the ASAP model has been widely applied nationwide and has become one of the routine testing items for physical examination screening and serological diagnosis of high-risk populations for liver cancer. With the intelligent information solution designed based on the ASAP model, not only can the risk of early liver cancer be predicted, but also the diagnosis and treatment path of liver cancer can be optimized, greatly improving the clinical diagnosis and treatment efficiency. The ASAP online mini program will also be launched, further expanding application channels.