These two age points are crucial. Chinese scholars have revealed the characteristics of women's aging patterns | China | Related | Manifestations | Clock | Hormones | Women | Research
Recently, the latest research by Chinese scholars on the laws and changes of female aging was published online in the journal "Medicine" under the umbrella of "Cell". For the first time, it systematically revealed biological markers such as hormone levels and immune ability in the aging process of Chinese women.
"In the study, we found that many aging indicators of individuals receiving hormone replacement therapy have become 'younger', and the 'clock' of aging has been pushed back to a certain extent." Zhang Weiqi, the co corresponding author of the paper and a researcher at the Chinese Academy of Sciences Beijing Genome Research Institute, told the Science and Technology Daily that the study has established a multi-level composite clock for Chinese women, such as facial clock, hormone clock, immune clock, etc., through which multi-dimensional aging assessment has higher prediction accuracy.
It is reported that the joint research team of the Institute of Zoology of the Chinese Academy of Sciences, the Beijing Genome Research Institute of the Chinese Academy of Sciences and the Quzhou People's Hospital has established a natural population queue covering Chinese women aged 20-66 years, requiring volunteers to live locally for a long time, have no major diseases, regulate food, drink and rest, etc., so as to reduce the impact of factors other than natural aging on research. After locking in the research queue, researchers systematically explored the multidimensional biomarkers of aging in Chinese women by studying the phenotype, transcriptome, proteome, metabolome, and microbiome of the subjects, combined with analysis methods such as artificial intelligence. The integration of multi omics data on aging accurately reveals the "essence" of aging, including inflammation activation, hormonal regulation disorders, and multi tissue functional degradation.
"For example, the reduction of immature T cells in the blood and the increase of toxic T cells are the main characteristics of immune cell aging." Liu Guanghui, the co corresponding author of the paper and a researcher at the Institute of Zoology, Chinese Academy of Sciences, introduced that, in addition, the up regulation of inflammation related proteins is positively related to aging, and the accumulation of lipids in plasma and the reduction of steroid hormone related metabolites are also important characteristics of aging.
The aging "clock" obtained from the study clearly points to the two key time points of 30 and 50 years old: aging around 30 years old is mainly manifested by lipid accumulation at the metabolic level and a decrease in steroid molecules; Around the age of 50, it manifests as drastic changes in organs, cells, and molecules.
"There were significant changes in aging related indicators at both time points," explained Zhang Weiqi. "We believe that these two time points are very consistent with fertility and menopause, during which there were significant fluctuations in women's endocrine levels, suggesting that hormone changes are a key influencing factor in women's aging."
Can the aging "clock" become a means of evaluating and delaying aging? Researchers compared volunteers who had received long-term hormone replacement therapy with those in the same age group who had not received treatment, and found that multiple aging related parameters of the former, such as inflammatory proteins and liver injury markers, improved towards a younger state. Their hormone clock, immune clock, metabolic clock, and other rates also showed varying degrees of delay. The study also found that supplementing plasma metabolites downregulated with aging can significantly delay the aging of human arterial endothelial cells and improve their function, indicating the potential of these metabolites to intervene in human vascular aging.
