My research team has developed a new method for producing lactic acid, called Cell | Lactic Acid | Method
Research progress
On June 13, the reporter of Science and Technology Daily learned from the Chinese Academy of Sciences Qingdao Institute of Bioenergy and Process Research that the metabolomics research group of the institute has developed a new method for the production of lactic acid from agricultural waste biomass, and realized the production of lignocellulosic L-lactic acid through integrated collaborative fermentation based on high-temperature anaerobic whole cell catalysis. The relevant research results were recently published online in the Journal of Environmental Management.
The large-scale biosynthesis of lactic acid has always relied on food carbon sources such as glucose and starch. The rapid development of China's economy and the proposal of the "dual carbon" goal have put forward new requirements for low-cost production of bulk chemicals such as lactic acid. Non grain carbon sources such as lignocellulose have advantages in carbon reduction and environmental protection, but they rely on efficient conversion of lignocellulose to fermentable sugars.
The research group has put forward a new integrated biological saccharification technology approach using fiber producing thermophilic Clostridium as a whole cell catalyst in response to the urgent need to establish an independent and efficient lignocellulosic sugar platform in China. This has led to the establishment of an efficient non grain sugar platform. CBS technology has been proven to be combined with microalgae, yeast, and bacterial fermentation, and has been applied to the production of lignocellulosic based pullulan polysaccharides, demonstrating its feasibility in achieving high-value conversion of lignocellulosic biomass.
On the basis of previous research, the research team further screened and isolated a high-temperature lactic acid production bacterium 2H-3 that matched the CBS conditions. Using corn straw, wheat straw, or xylose residue as substrates, the saccharification solution was obtained through CBS technology, and the fermentation production of lactic acid was achieved by directly inoculating 2H-3 cells without intermediate sterilization, nutrient supplementation, or fermentation conditions adjustment. As a result, high optical purity, high yield, and high yield of lignocellulosic based lactic acid production were successfully achieved.
Research progress
On June 13, the reporter of Science and Technology Daily learned from the Chinese Academy of Sciences Qingdao Institute of Bioenergy and Process Research that the metabolomics research group of the institute has developed a new method for the production of lactic acid from agricultural waste biomass, and realized the production of lignocellulosic L-lactic acid through integrated collaborative fermentation based on high-temperature anaerobic whole cell catalysis. The relevant research results were recently published online in the Journal of Environmental Management.
The large-scale biosynthesis of lactic acid has always relied on food carbon sources such as glucose and starch. The rapid development of China's economy and the proposal of the "dual carbon" goal have put forward new requirements for low-cost production of bulk chemicals such as lactic acid. Non grain carbon sources such as lignocellulose have advantages in carbon reduction and environmental protection, but they rely on efficient conversion of lignocellulose to fermentable sugars.
The research group has put forward a new integrated biological saccharification technology approach using fiber producing thermophilic Clostridium as a whole cell catalyst in response to the urgent need to establish an independent and efficient lignocellulosic sugar platform in China. This has led to the establishment of an efficient non grain sugar platform. CBS technology has been proven to be combined with microalgae, yeast, and bacterial fermentation, and has been applied to the production of lignocellulosic based pullulan polysaccharides, demonstrating its feasibility in achieving high-value conversion of lignocellulosic biomass.
On the basis of previous research, the research team further screened and isolated a high-temperature lactic acid production bacterium 2H-3 that matched the CBS conditions. Using corn straw, wheat straw, or xylose residue as substrates, the saccharification solution was obtained through CBS technology, and the fermentation production of lactic acid was achieved by directly inoculating 2H-3 cells without intermediate sterilization, nutrient supplementation, or fermentation conditions adjustment. As a result, high optical purity, high yield, and high yield of lignocellulosic based lactic acid production were successfully achieved.