Let the aging brain "reverse time"? The key may be its factors | platelets | aging brain

[Editor in Chief Circle]

Can an aging brain reverse time and become younger? The key may be a platelet factor. According to three papers published simultaneously in Nature, Nature Aging, and Nature Communications on the 16th, three research teams from the University of California, San Francisco and the University of Queensland in Australia have identified platelet factor IV as a common messenger for reversing aging - three independent interventions for aging, including long-lived protein klotho injection, young blood delivery, and exercise, all focusing on this platelet factor.

PF4 is stored in platelets, and this study has shocked scientists: PF4 is actually a "cognitive enhancer". Under its influence, older mice have regained their sensitivity in middle age, while younger mice have become smarter.

In three anti-aging studies, the lifespan protein klotho is a natural protein expressed in kidney and brain tissues. Previous studies have found that klotho protein fragment therapy can improve brain function in both young and old mice. But scientists know that its effect is definitely indirect, because the klotho molecules injected into the body never reach the brain. Now, the team has discovered that the link is PF4: released by platelets after injection of klotho.

Another study comes from the field of interspecies symbiosis, which involves experiments that link two animals together through blood circulation, where older animals become younger and their brains are more capable of learning. In subsequent studies, the team found that younger plasma contains more PF4, and the recovery effect of only injecting PF4 into older animals is also very significant. The team selected 22 month old mice, equivalent to people in their 70s, and PF4 restored their functions to those in their 30s to 40s.

In sports research, it is known that exercise can maintain mental agility, but the latest research has found that the key is that platelets release PF4 into the bloodstream after exercise. This team also found that PF4 improved the cognitive abilities of elderly animals in separate tests.

Researchers have concluded that people can now "target" the effectiveness of platelets to offset age-related cognitive decline.

The attraction of combating the brain's decline caused by aging is enormous. This discovery is said to have surprised scientists. Simply put, the anti-aging effect of the blood factor PF4 is to make the immune system look younger. It reduces all active anti-aging immune factors, reduces brain inflammation, enhances plasticity, and ultimately improves cognitive ability. Some people may say, isn't exercise the easiest and least effective way? But for many people with health problems, limited mobility, or advanced age, exercise is almost impossible, and discovering common anti-aging keys from different perspectives is the starting point for drug development that applies to everyone.

[Editor in Chief Circle]

Can an aging brain reverse time and become younger? The key may be a platelet factor. According to three papers published simultaneously in Nature, Nature Aging, and Nature Communications on the 16th, three research teams from the University of California, San Francisco and the University of Queensland in Australia have identified platelet factor IV as a common messenger for reversing aging - three independent interventions for aging, including long-lived protein klotho injection, young blood delivery, and exercise, all focusing on this platelet factor.

PF4 is stored in platelets, and this study has shocked scientists: PF4 is actually a "cognitive enhancer". Under its influence, older mice have regained their sensitivity in middle age, while younger mice have become smarter.

In three anti-aging studies, the lifespan protein klotho is a natural protein expressed in kidney and brain tissues. Previous studies have found that klotho protein fragment therapy can improve brain function in both young and old mice. But scientists know that its effect is definitely indirect, because the klotho molecules injected into the body never reach the brain. Now, the team has discovered that the link is PF4: released by platelets after injection of klotho.

Another study comes from the field of interspecies symbiosis, which involves experiments that link two animals together through blood circulation, where older animals become younger and their brains are more capable of learning. In subsequent studies, the team found that younger plasma contains more PF4, and the recovery effect of only injecting PF4 into older animals is also very significant. The team selected 22 month old mice, equivalent to people in their 70s, and PF4 restored their functions to those in their 30s to 40s.

In sports research, it is known that exercise can maintain mental agility, but the latest research has found that the key is that platelets release PF4 into the bloodstream after exercise. This team also found that PF4 improved the cognitive abilities of elderly animals in separate tests.

Researchers have concluded that people can now "target" the effectiveness of platelets to offset age-related cognitive decline.

The attraction of combating the brain's decline caused by aging is enormous. This discovery is said to have surprised scientists. Simply put, the anti-aging effect of the blood factor PF4 is to make the immune system look younger. It reduces all active anti-aging immune factors, reduces brain inflammation, enhances plasticity, and ultimately improves cognitive ability. Some people may say, isn't exercise the easiest and least effective way? But for many people with health problems, limited mobility, or advanced age, exercise is almost impossible, and discovering common anti-aging keys from different perspectives is the starting point for drug development that applies to everyone.