It will increase therapeutic targets for broad-spectrum COVID-19 drugs. Chinese scientists found COVID-19 New Host Factor Team | COVID-19 | Host

Release time:Apr 13, 2024 23:36 PM

Recently, the team led by Peng Xiaozhong, Lu Shuaiyao, Hu Yunzhang, and Shi Jiandong from the Institute of Medical Biology, Chinese Academy of Medical Sciences, published their latest research in the sub issue of Science Progress. The team found that aromatic hydrocarbon receptors are host factors and potential therapeutic targets of COVID-19, which will provide new potential therapeutic targets for screening broad-spectrum anti coronavirus drugs.

The research team introduced that in the process of the epidemic and evolution of COVID-19, a variety of variants emerged constantly, posing a serious challenge to global public health. At the same time, the complete pathogenesis of COVID-19 remains to be studied, especially the key cells and molecules at the early stage of virus infection have not been deciphered. Effective and specific antiviral drugs against COVID-19 are still limited. In order to deal with the emerging variants, find the therapeutic targets of broad-spectrum anti COVID-19 variants, and develop broad-spectrum COVID-19 therapeutic drugs will become the key to curb the COVID-19 pandemic.

Aromatic hydrocarbon receptors are sensing tryptophan metabolites and are immune regulatory molecules. Previously, the role of aromatic hydrocarbon receptors in COVID-19 infection and whether they can be used as antiviral therapeutic targets for COVID-19 and its variants was unclear. The research team found that COVID-19 infection activated the aromatic hydrocarbon receptor signal, and pharmacological aromatic hydrocarbon receptor blocking or "gene knockout" of the receptor reduced the replication of COVID-19 and its variants.


It will increase therapeutic targets for broad-spectrum COVID-19 drugs. Chinese scientists found COVID-19 New Host Factor Team | COVID-19 | Host

In addition, the research team used aromatic hydrocarbon receptor antagonists to target this receptor, which significantly reduced the replication of COVID-19 and its variants in hamsters, and reversed the lung inflammation of hamsters caused by COVID-19 infection. Therefore, research results show that aromatic hydrocarbon receptors are host dependent factors of COVID-19 and candidate targets for antiviral therapy against COVID-19 and its variants. It is worth noting that the activation of host cell aromatic hydrocarbon receptors and downstream signal pathway gene expression after coronavirus infection is not a unique feature of COVID-19, and this phenomenon has also been observed in other coronaviruses.

The research team stated that aromatic hydrocarbon receptors are potential host dependent factors for broad-spectrum coronavirus, providing a potential target for screening broad-spectrum anti coronavirus drugs. At present, antiviral drugs targeting viral protein RNA polymerase and 3CL protease face many problems such as susceptibility to drug resistance. Finding host based antiviral targets is also an important approach to solving the problem of viral resistance.

Two women were stabbed to death and reported to have committed a crime 4 days before the follow-up visit for schizophrenia. Suspect of a bloody murder case in a Hong Kong shopping mall appeared in court today. Male | Last Friday | Murder case
Two women were stabbed to death and reported to have committed a crime 4 days before the follow-up visit for schizophrenia. Suspect of a bloody murder case in a Hong Kong shopping mall appeared in court today. Male | Last Friday | Murder case

According to Hong Kong's Wen Wei Po, a bloody knife stabbing case occurred at Hollywood Square in Diamond Hill last Friday. The police arrested a 39 year old man on suspicion of stabbing two young women, one of whom was stabbed over 30 times. The suspect appeared in the Kwun Tong Magistrates Court this morning. The police at the Kwun Tong Magistrate's Court temporarily charged the suspect with two counts of murder last Sunday. The suspect appeared in court this morning at the Kwun Tong Magistrate's Court. Acting Chief Magistrate Zheng Jihang, after listening to the opinions of both the prosecution and defense, decided to postpone the hearing for two weeks until 9:30 am on June 19th, waiting for two psychiatric expert reports to be obtained. The defense did not object. Zheng Jihang approved the application, and the defendant needs to be temporarily detained at Xiaolan Mental Hospital. When the suspect appeared in court, he wore black framed glasses, a light gray shirt, and camouflage green shorts, and was able to answer the judge's questions normally. accordingly

Secretary of the Provincial Party Committee: The focus of Henan's "summer harvest" has shifted to agricultural machinery in the northern region of Henan Province. | Support | Science | Organization | Province | Northern Henan | Summer Harvest | Rush Harvest
Secretary of the Provincial Party Committee: The focus of Henan's "summer harvest" has shifted to agricultural machinery in the northern region of Henan Province. | Support | Science | Organization | Province | Northern Henan | Summer Harvest | Rush Harvest

Currently, the highly anticipated summer harvest work in Henan has shifted its focus to the northern region of Henan. According to the Henan Daily client, on June 4th, Lou Yangsheng, Secretary of the Henan Provincial Party Committee, presided over a special video scheduling meeting on the "Three Summers" work in the province, listened to the situation report, analyzed and judged the situation, and arranged and deployed the next steps of work. Governor Wang Kai made specific arrangements. On the evening of May 31, 2023, in Xiafutou Village, Xuliang Town, Boai County, Jiaozuo, Henan Province, villagers braved light rain in the wheat fields to harvest wheat. Visual China Map Lou Yangsheng pointed out that the current summer harvest battle in the province has entered the decisive stage. Doing a good job in summer harvest in northern Henan Province is related to the summer grain yield and seed safety. We should focus on seizing opportunities and make every effort to organize the wheat harvesting work in the northern Henan region, minimize losses, and protect the interests of farmers to the greatest extent possible. Accurate forecasting is essential

Xinhua All Media+| Welcome home! What innovative technologies are protecting the return journey of Shenzhou 15? Spaceship | Shenzhou | Technology
Xinhua All Media+| Welcome home! What innovative technologies are protecting the return journey of Shenzhou 15? Spaceship | Shenzhou | Technology

On June 4th, the return capsule of the Shenzhou-15 manned spacecraft successfully landed at the Dongfeng landing site. Astronauts Fei Junlong, Deng Qingming, and Zhang Lu all safely and smoothly exited the spacecraft, and the Shenzhou-15 manned flight mission was a complete success. What innovative technologies are there to safeguard the return journey of Shenzhou 15 in this mission? On June 4th, the return capsule of the Shenzhou-15 manned spacecraft successfully landed at the Dongfeng landing site. Xinhua News Agency reporter Lian Zhen photographed that "the sky and the ground" ensure the high-precision return of spacecraft. For the Shenzhou series spacecraft, the return and re-entry GNC technology is directly related to the life safety of astronauts. Taking the success of this return mission as a symbol, China has comprehensively upgraded its GNC system since the Shenzhou-12 manned spacecraft, which features autonomous rapid rendezvous and docking, autonomous adaptive prediction and re-entry return guidance, and has completed a comprehensive update and replacement

The Chinese naval fleet has arrived! Assembly | Navy | Chinese Fleet
The Chinese naval fleet has arrived! Assembly | Navy | Chinese Fleet

At noon today, a Chinese naval fleet consisting of Zhanjiang and Xuchang ships arrived at the assembly area of the "Comodo-2023" multinational maritime joint exercise. It is understood that the assembly anchorage for this exercise is 3 nautical miles long and 1.5 nautical miles wide, capable of anchoring up to 50 ships. Naval vessels from various countries participating in the exercise will also arrive at the anchorage today to complete the assembly of the "Komodo 2023" multinational maritime joint exercise, which is held every two years by the Indonesian Navy. This year is already the fourth edition of the exercise. The exercise will be held from June 5th to 8th in the city of Jakarta, South Sulawesi Province, Indonesia, including the port and sea phases. In the coming days, participating navies from various countries will participate in ship reading style search and rescue exercises, maritime interception and damage management exercises, aerial exercises, and other course objectives exercises

New comment: Donkey like "morale" limit pulls US debt "bomb" fuse hard to dismantle US | debt | morale
New comment: Donkey like "morale" limit pulls US debt "bomb" fuse hard to dismantle US | debt | morale

On the evening of June 1st, the US Senate passed a bill on the federal government's debt ceiling and budget, and the flame of the US debt bomb was temporarily extinguished at the last moment. The two parties in the United States have staged an extreme tug of war over the US debt bomb. Some experts believe that the US debt crisis is the result of the reckless politics promoted by the US dollar hegemony, and the underlying cause of this crisis is the highly polarized political system of the US. Since the end of World War II, the US Congress has adjusted the debt ceiling more than a hundred times. The recurring debt crisis will not only have a catastrophic impact on the US economy and people's livelihoods, but also continuously erode the value of US dollar assets such as government credit and US bonds, bringing significant and far-reaching impacts to the global economic landscape. 【