Is "lying thin" a reality? Two weight loss pills have been submitted for application! Management | Weight | Weight loss pills

Release time:Apr 15, 2024 06:57 AM

On August 21st, the official website of the Drug Evaluation Center of the National Medical Products Administration showed that the registration application of Lilly's tirzepatide injection for long-term weight management of overweight patients with adult obesity or at least one weight related comorbidities has been officially accepted. Telposide has also become another weight loss drug for weight management that has been applied for in China, following Novo Nordisk's Smegglutide. According to a real world study of 15.8 million people published in the journal diabetes, Obesity and Metabolism by Chen Kang, et al., Department of Endocrinology, First Medical Center, General Hospital of the Chinese People's Liberation Army on August 17, the proportion of overweight men in China exceeded 40%. Telposide is currently the world's first and only glucose dependent insulinotropic peptide and glucagon like peptide-1 dual target receptor agonist for long-term weight management in adult obese or overweight patients, administered once a week. In September 2022, Lilly submitted an application for blood glucose control registration of tilporide for the treatment of adult type 2 diabetes patients in China, which is also under review. In May 2022, Tilpoltide was approved by the US Food and Drug Administration to improve the blood sugar control of adult patients with type 2 diabetes, and has been approved in the EU, Japan, etc. In October 2022, the US FDA granted Telposide a fast track qualification for improving long-term weight management indications in overweight adults who are obese or have at least one comorbidities, in order to accelerate the approval of this indication. Lilly's later clinical trials have shown that while achieving blood sugar control goals, telposide can also help obese patients lose weight. The results of an international clinical trial for ordinary obese people without type 2 diabetes showed that the average weight of the subgroup receiving the highest dose of tilporide was reduced by 22.5%, and 63% of the subjects lost at least 20% of their weight, which was the first drug under study to reduce the average weight by more than 20% in the phase III clinical trial. In addition, the results of the registered clinical trial SURBOUNT-CN of Tilpodide for obesity or overweight in China will be announced at the academic annual meeting of the European diabetes Research Association in October this year, which included 210 Chinese patients. Lilly said that obesity will increase the risk of diabetes and a variety of metabolic diseases. Therefore, by treating obesity, the chance of metabolic diseases and related complications can be reduced, so as to improve people's health. Wall Street has also raised its sales forecast for telposide as a result. According to research firm Refinitiv, analysts currently estimate that telposide's sales will reach $4.7 billion in 2026. In China, the incidence of obesity and overweight is also becoming increasingly common. According to the above real world research on 15.8 million people in diabetes, Obesity and Metabolism magazine, according to the BMI classification standard of overweight and obesity in China, overweight people accounted for 34.8% of the subjects and obese people accounted for 14.1%; Among them, 41.1% are overweight males and 27.7% are overweight females; The proportion of obese males is 18.2%, while females account for 9.4%. The study also found that the most common complications of overweight/obese participants were fatty liver, pre diabetes, dyslipidemia and hypertension, and the number of complications increased with the increase of body mass index. Due to its optimistic outlook on the potential of China's obesity treatment market, Novo Nordisk also submitted a marketing application for the weekly injection of Smegglutide 2.4mg for long-term weight management in China in June this year, which was accepted by the National Medical Products Administration. Previously, the drug "Novotel" used by Smeaglutide for hypoglycemic indications has been listed in China and included in the


Is "lying thin" a reality? Two weight loss pills have been submitted for application! Management | Weight | Weight loss pills
Two women were stabbed to death and reported to have committed a crime 4 days before the follow-up visit for schizophrenia. Suspect of a bloody murder case in a Hong Kong shopping mall appeared in court today. Male | Last Friday | Murder case
Two women were stabbed to death and reported to have committed a crime 4 days before the follow-up visit for schizophrenia. Suspect of a bloody murder case in a Hong Kong shopping mall appeared in court today. Male | Last Friday | Murder case

According to Hong Kong's Wen Wei Po, a bloody knife stabbing case occurred at Hollywood Square in Diamond Hill last Friday. The police arrested a 39 year old man on suspicion of stabbing two young women, one of whom was stabbed over 30 times. The suspect appeared in the Kwun Tong Magistrates Court this morning. The police at the Kwun Tong Magistrate's Court temporarily charged the suspect with two counts of murder last Sunday. The suspect appeared in court this morning at the Kwun Tong Magistrate's Court. Acting Chief Magistrate Zheng Jihang, after listening to the opinions of both the prosecution and defense, decided to postpone the hearing for two weeks until 9:30 am on June 19th, waiting for two psychiatric expert reports to be obtained. The defense did not object. Zheng Jihang approved the application, and the defendant needs to be temporarily detained at Xiaolan Mental Hospital. When the suspect appeared in court, he wore black framed glasses, a light gray shirt, and camouflage green shorts, and was able to answer the judge's questions normally. accordingly

Secretary of the Provincial Party Committee: The focus of Henan's "summer harvest" has shifted to agricultural machinery in the northern region of Henan Province. | Support | Science | Organization | Province | Northern Henan | Summer Harvest | Rush Harvest
Secretary of the Provincial Party Committee: The focus of Henan's "summer harvest" has shifted to agricultural machinery in the northern region of Henan Province. | Support | Science | Organization | Province | Northern Henan | Summer Harvest | Rush Harvest

Currently, the highly anticipated summer harvest work in Henan has shifted its focus to the northern region of Henan. According to the Henan Daily client, on June 4th, Lou Yangsheng, Secretary of the Henan Provincial Party Committee, presided over a special video scheduling meeting on the "Three Summers" work in the province, listened to the situation report, analyzed and judged the situation, and arranged and deployed the next steps of work. Governor Wang Kai made specific arrangements. On the evening of May 31, 2023, in Xiafutou Village, Xuliang Town, Boai County, Jiaozuo, Henan Province, villagers braved light rain in the wheat fields to harvest wheat. Visual China Map Lou Yangsheng pointed out that the current summer harvest battle in the province has entered the decisive stage. Doing a good job in summer harvest in northern Henan Province is related to the summer grain yield and seed safety. We should focus on seizing opportunities and make every effort to organize the wheat harvesting work in the northern Henan region, minimize losses, and protect the interests of farmers to the greatest extent possible. Accurate forecasting is essential

Xinhua All Media+| Welcome home! What innovative technologies are protecting the return journey of Shenzhou 15? Spaceship | Shenzhou | Technology
Xinhua All Media+| Welcome home! What innovative technologies are protecting the return journey of Shenzhou 15? Spaceship | Shenzhou | Technology

On June 4th, the return capsule of the Shenzhou-15 manned spacecraft successfully landed at the Dongfeng landing site. Astronauts Fei Junlong, Deng Qingming, and Zhang Lu all safely and smoothly exited the spacecraft, and the Shenzhou-15 manned flight mission was a complete success. What innovative technologies are there to safeguard the return journey of Shenzhou 15 in this mission? On June 4th, the return capsule of the Shenzhou-15 manned spacecraft successfully landed at the Dongfeng landing site. Xinhua News Agency reporter Lian Zhen photographed that "the sky and the ground" ensure the high-precision return of spacecraft. For the Shenzhou series spacecraft, the return and re-entry GNC technology is directly related to the life safety of astronauts. Taking the success of this return mission as a symbol, China has comprehensively upgraded its GNC system since the Shenzhou-12 manned spacecraft, which features autonomous rapid rendezvous and docking, autonomous adaptive prediction and re-entry return guidance, and has completed a comprehensive update and replacement

The Chinese naval fleet has arrived! Assembly | Navy | Chinese Fleet
The Chinese naval fleet has arrived! Assembly | Navy | Chinese Fleet

At noon today, a Chinese naval fleet consisting of Zhanjiang and Xuchang ships arrived at the assembly area of the "Comodo-2023" multinational maritime joint exercise. It is understood that the assembly anchorage for this exercise is 3 nautical miles long and 1.5 nautical miles wide, capable of anchoring up to 50 ships. Naval vessels from various countries participating in the exercise will also arrive at the anchorage today to complete the assembly of the "Komodo 2023" multinational maritime joint exercise, which is held every two years by the Indonesian Navy. This year is already the fourth edition of the exercise. The exercise will be held from June 5th to 8th in the city of Jakarta, South Sulawesi Province, Indonesia, including the port and sea phases. In the coming days, participating navies from various countries will participate in ship reading style search and rescue exercises, maritime interception and damage management exercises, aerial exercises, and other course objectives exercises

New comment: Donkey like "morale" limit pulls US debt "bomb" fuse hard to dismantle US | debt | morale
New comment: Donkey like "morale" limit pulls US debt "bomb" fuse hard to dismantle US | debt | morale

On the evening of June 1st, the US Senate passed a bill on the federal government's debt ceiling and budget, and the flame of the US debt bomb was temporarily extinguished at the last moment. The two parties in the United States have staged an extreme tug of war over the US debt bomb. Some experts believe that the US debt crisis is the result of the reckless politics promoted by the US dollar hegemony, and the underlying cause of this crisis is the highly polarized political system of the US. Since the end of World War II, the US Congress has adjusted the debt ceiling more than a hundred times. The recurring debt crisis will not only have a catastrophic impact on the US economy and people's livelihoods, but also continuously erode the value of US dollar assets such as government credit and US bonds, bringing significant and far-reaching impacts to the global economic landscape. 【