How to break through the traditional linear scientific research paradigm and PI system?, Linear | Discipline | Traditional in the Era of Coexistence of Large and Small Sciences

Release time:Apr 14, 2024 06:17 AM

Recently, under the guidance of the Shanghai Municipal Commission of Science and Technology, an interdisciplinary exchange activity was held at the Shanghai Institute of Science and Technology. Liu Xiaolong, director of the Center for Excellence and Innovation in Molecular Cell Science of the Chinese Academy of Sciences, led more than 20 young scientists studying life science, and had in-depth exchanges with more than 10 young scientists studying new generation information technology, such as artificial intelligence, high-performance computing systems, quantum computing, and so on, to explore the cooperation direction of applying the new generation of information technology to life science research.

The Third Plenary Session of the 12th Shanghai Municipal Party Committee proposed that there is currently a problem of paradigm lag in strengthening the function of science and technology innovation policy sources. Many scientific research organizations still adopt the traditional linear paradigm or PI system, which results in low collaborative efficiency of innovation across fields, levels, and disciplines.

How to break through the traditional linear paradigm or PI system and enhance the collaborative efficiency of cross-border innovation? Jiefang Daily's Shangguan News reporter interviewed young scientists from Shanghai Institute of Intelligence and Strategic Planning Experts from Shanghai Institute of Science.

Breaking through the traditional PI system and promoting interdisciplinary cooperation

According to Zhang Huanchen, an assistant professor at Tsinghua University and a graduate of Carnegie Mellon University, the PI system is a widely adopted research organization model internationally, particularly in the fields of natural sciences and basic research. It is an abbreviation for the term "Principal Investigator" in English, which can be translated as "academic leader" or "chief scientist".

PI first appeared in research project applications in European and American countries. The National Institutes of Health in the United States defines PI as "an individual recognized by the applicant institution who has certain powers and responsibilities to guide projects supported by the fund." Regardless of whether the applicant is a professor, associate professor, or assistant professor, as long as the project funding is obtained, the applicant can become PI. "In American universities, a PI often teaches several doctoral students. If he applies for a large amount of research project funding, he can also recruit several researchers." Zhang Huanchen said, "China's PI system comes from Europe and America, providing institutional guarantees for scientists to conduct independent research."


How to break through the traditional linear scientific research paradigm and PI system?, Linear | Discipline | Traditional in the Era of Coexistence of Large and Small Sciences

As a new research and development institution, Shanghai Jizhi Research Institute also adopts the PI system, and now has 34 PIs, including 3 academicians of the CAS Member and 31 young scientists. However, unlike the traditional PI system, Turing Award winner and director of the Shanghai Institute of Intelligence, Yao Qizhi, encourages cross disciplinary cooperation between PI and researchers from other disciplines both inside and outside the institute, and has established a cross intelligence direction. Three PIs lead the research in artificial intelligence biology, ancient DNA big data analysis and application of East Asian populations, and meteorological big data and artificial intelligence.

The PI team of Shanghai Qizhi Research Institute is researching reinforcement learning algorithms.

The reason for breaking through the traditional PI system is because in many scientific research fields such as artificial intelligence, the importance of interdisciplinary research is increasingly prominent. The "AI4S" that has become popular in the scientific community this year is an example. Zhu Xueyan, Director of the Strategic Planning Research Office of the Shanghai Institute of Science, said that "AI4S" is a new scientific research paradigm, different from previous research paradigms such as experiments, theory, simulation, and data-driven. It closely integrates artificial intelligence with various disciplinary fields and is expected to create a large amount of new scientific knowledge and technology.

Based on the new scientific research paradigm, the Basic Research Division of the Municipal Science and Technology Commission organized cross-border exchanges between the Shanghai Jizhi Research Institute and the Molecular Cell Science Innovation Center of the Chinese Academy of Sciences. This type of activity can break through traditional linear paradigms or PI systems, allowing researchers to break out of their research fields and collide with researchers from different disciplines to spark ideas. "Our cross-border cooperation can also involve humanities, social sciences, and arts, such as using AI technology to decipher ancient Chinese characters such as oracle bone script and Mayan script," said Chen Yilei, an assistant professor at Shanghai Qizhi Research Institute and Tsinghua University.

Disrupting linear paradigms and enhancing innovation synergy efficiency

In Zhu Xueyan's view, technological innovation is a complex system rather than a simple input-output relationship, so linear paradigms are no longer applicable to many current scientific research activities, and are replaced by systematic paradigms. "In this era of coexistence of big and small sciences, the PI system, a small scientific research organization model, is still effective. However, research activities that gather numerous researchers, invest a large amount of funds, and utilize large scientific facilities are becoming increasingly valuable. This is because the complexity of technological innovation has greatly increased compared to the past. To explore new scientific knowledge, it is necessary to adopt a systematic paradigm, organize big scientific research, initiate and implement big scientific plans, and seek breakthroughs at the boundaries of natural sciences such as material, information, and life."


How to break through the traditional linear scientific research paradigm and PI system?, Linear | Discipline | Traditional in the Era of Coexistence of Large and Small Sciences

Large scientific facilities: Shanghai Synchrotron Radiation Light Source and X-ray Free Electron Laser Test Facility

In this context, it is particularly important to enhance the collaborative efficiency of innovation across fields, levels, and disciplines. "In terms of innovation collaboration, Shanghai still needs to vigorously strengthen its function as a source of science and technology innovation." Zhu Xueyan bluntly stated that the government and relevant institutions can start from the government's strategic layout, new national system, risk sharing mechanism, and other aspects to study and improve the system and measures to enhance the efficiency of innovation collaboration.

In terms of government strategic layout, it is necessary to optimize the system and mechanism for selecting fields, projects, and talents in basic research, strengthen the forward-looking, strategic, and systematic layout of cutting-edge science and technology projects, and more layout in interdisciplinary fields, especially in non consensus areas, in order to breed original and disruptive scientific and technological achievements.

In the new national system, it is necessary to focus on strategic products and tasks that have market failures and clear goals, organize cross domain, cross level, and cross disciplinary "big army operations" for key core technologies, research and develop scientific and reasonable funding allocation plans, and strengthen cooperation between participating units and research and development personnel through top-level design, so as to effectively unite different technological forces.

In terms of risk sharing mechanisms, new policies can be explored to loosen the constraints on state-owned asset management, encouraging state-owned assets to dare to "invest early, invest small, and invest hard", and work together with social capital to promote early projects in the field of hard technology and accelerate the growth of small enterprises; At the same time, by creating a better market environment and supporting more venture capital institutions to develop in Shanghai, the construction of Shanghai's science and technology innovation center will be better matched with the construction of the financial center.

Shanghai International Sister City Youth "Play" Summer Camp Experience Traditional Culture, Make Pankou, Learn Paper Cuttings, Make Dumplings International | Youth | Make Dumplings
Shanghai International Sister City Youth "Play" Summer Camp Experience Traditional Culture, Make Pankou, Learn Paper Cuttings, Make Dumplings International | Youth | Make Dumplings

Making coils, learning Paper Cuttings, making dumplings, walking into the home of summer camp volunteers and feeling the life of Shanghai people... On the 20th, the 2023 Shanghai International Sister City Youth Summer Camp officially opened in Shanghai Shidong Experimental School. 73 campers from 13 cities in 12 countries gathered in Shanghai to open the annual international sister city youth exchange event with their peers in Shanghai. The young partners together carried out activities such as learning excellent traditional Chinese culture courses such as Chinese and traditional Chinese painting, intangible cultural heritage, Chinese clothing, disco, Paper Cuttings, seal cutting, calligraphy, pottery, tea art, Yanzhi, dragon dance, youth forum exchanges in sister cities, investigation of urban cultural landscape, visits to universities and venues, city orientation challenges, and local family life experiences, etc., to bloom their youth. In addition to a rich and colorful summer camp physical activity experience, campers and volunteers

Undergraduate voluntary application starts today! These important reminders and suggestions must be read, @ College Entrance Examination Stage | Undergraduate | Volunteer
Undergraduate voluntary application starts today! These important reminders and suggestions must be read, @ College Entrance Examination Stage | Undergraduate | Volunteer

@All college entrance examination candidates, according to the schedule of the college entrance examination, will fill in their undergraduate preferences for all batches except for the comprehensive evaluation batch from 8:00 a.m. to 8:00 p.m. daily from July 1st to 2nd, and from 8:00 a.m. to 12:00 a.m. on July 3rd. The specific contents of this voluntary application include zero voluntary batch, advance batch, art and sports class A batch, local rural special plan batch, special type enrollment, and ordinary batch. The filling method is as follows: Fresh high school graduates in this city will be arranged uniformly by the high school where they are enrolled; Non local fresh high school graduates will be arranged uniformly by the district recruitment office where they apply. It is important to remind candidates that during the voluntary application period from July 1st to 3rd, as the admission of the comprehensive evaluation batch has not yet been completed, candidates who have filled out the comprehensive evaluation batch of voluntary applications still need to carefully fill out other batches of undergraduate voluntary applications

Investment+Services Drive Anti Cancer Drugs into Clinical Practice | Entrepreneurial Stories in Incubators, Second Entrepreneurial Biology for CEOs of Listed Companies | Incubators | Clinical | Incubators
Investment+Services Drive Anti Cancer Drugs into Clinical Practice | Entrepreneurial Stories in Incubators, Second Entrepreneurial Biology for CEOs of Listed Companies | Incubators | Clinical | Incubators

Recently, with the approval of the National Medical Products Administration, the Class 1 innovative drug CC312 developed by Huihe Biotechnology has initiated phase I clinical trials for the treatment of recurrent/refractory CD19 positive B-cell malignant hematological tumors. This is the first domestically and the third globally approved triple specific antibody drug based on CD28 co stimulatory signals to enter clinical practice. When it comes to the development history of this new triple antibody drug, Dr. Zhu Huaxing, the founder of Huihe Biotechnology, still remembers vividly: "Before 2019, there was no triple antibody drug approved for clinical use globally, and some investors couldn't understand CC312. During a critical period of company development, Nokai Xinkang Fund invested 30 million yuan to help us complete Series A financing." Nokai Xinkang is a venture capital fund initiated by Xinze Entrepreneurship Incubator. This incubation company, which has been deeply cultivated in Zhangjiang Science City for many years

"Zidong Taichu" Full Modal Large Model Released, Precisely Positioned 3D Scene, Listening to "Moonlight Song" and Talking about Beethoven Images | Applications | Beethoven
"Zidong Taichu" Full Modal Large Model Released, Precisely Positioned 3D Scene, Listening to "Moonlight Song" and Talking about Beethoven Images | Applications | Beethoven

Not only can you hear Beethoven talk freely in "Moonlight", but you can also achieve precise positioning in three-dimensional scenes, and complete scene analysis through the combination of images and sound. On June 16, at the AI Framework Ecological Summit, the Institute of Automation of the Chinese Academy of Sciences officially released the full mode large model of "Zidong Taichu". This model is the 2.0 version upgraded from the 1.0 version of the 100 billion parameter multimodal model "Zidong Taichu". On the basis of voice, image and text three modes, it adds video, sensor signal, 3D point cloud and other modal data, breaks through the key technologies such as multimodal correlation for cognitive enhancement, and has full modal understanding, generation and correlation capabilities. At the meeting, Xu Bo, the director of the Institute of Automation, presented for the first time in real time the "Zidong Taichu" full modal cognitive model in music understanding

Perseverance is a life experience. Lingling Middle School has weak muscles. Candidates complete the college entrance examination: no matter what difficulties they experience. High school | school | college entrance examination
Perseverance is a life experience. Lingling Middle School has weak muscles. Candidates complete the college entrance examination: no matter what difficulties they experience. High school | school | college entrance examination

"The college entrance examination is an experience in our lives. Looking back on the preparation for the entire senior year of high school, we cannot help but marvel at the preciousness of time. No matter what difficulties we have gone through, I believe that as long as we persist, it will become my lifelong wealth. Today, after completing the morning foreign language listening and speaking test of the college entrance examination, Xiao Song, a senior student of Lingling High School, came out of the examination center of East China University of Science and Technology Affiliated Middle School. The senior year graduate sitting in a wheelchair said," Although academic and life are not small tests for me, I have faced many difficulties in adversity and have never given up on my dream of taking the college entrance examination. "Xiao Song suffered from congenital muscular dystrophy since childhood and entered Lingling High School in high school." Later, the school provided him with classrooms on low floors and close to the toilet, making it easier for him to enter and exit, allowing him to face his academic life with more confidence. At school, I met many kind and enthusiastic people