Severe patients with systemic lupus erythematosus with multiple organ failure have improved, and after 8 days and nights of sleepless rescue, respiratory failure | patient | systemic

Release time:Apr 14, 2024 07:38 AM

"Three beds in the emergency room, a patient with systemic lupus erythematosus, fever, respiratory failure, requesting consultation." A text message popped up in the emergency consultation group of the Rheumatology Department of Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine. The rheumatology consultant who was on ward rounds immediately rushed to the emergency room of the southern hospital. A 67 year old female with systemic lupus erythematosus, who had been taking glucocorticoids and immunosuppressants for a long time, experienced sudden high fever and breathing difficulties. This is the most critically ill patient with rheumatism. The emergency rheumatism green channel quickly opens, and the patient is immediately sent to the first rheumatism critical care unit in China: ECMO, ventilator, and CRRT. After 8 days and nights of rescue, the patient gradually improved.

 

Severe lung infections are the most deadly, and these medical teams relay rescue

Severe lung infections are the deadliest, and these medical teams are working together to rescue them

When the consulting doctor rushed to the emergency room and looked at the beating numbers on the patient's monitor, his heart sank. "Severe lung infection." This is fatal for immunosuppressive rheumatic patients. A series of emergency measures such as respiratory support, pathogen identification, active anti infection, and primary disease treatment were all used at the first time. However, due to the severity of the condition, the patient developed heart failure and acute renal failure. At this time, the tracheal intubation ventilator assisted breathing and 100% pure oxygen inhalation, and the patient's oxygen saturation was still less than 80%. Pulmonary imaging also confirmed widespread diffuse exudation in both lungs.

"There is no choice! Go to ECMO." Wang Xiaodong, Deputy Chief Physician of Rheumatology, immediately initiated the multidisciplinary SOS treatment process for critically ill patients. Chief Cardiovascular Surgery Physician Wang Weijun and Deputy Chief Physician Liu Jidong rushed over, and Emergency Department attending physician Xie Cuiying cancelled the flight. After one hour of intensive operation, the Rheumatology Intensive Care Team, Emergency Team, and ECMO Team successfully connected and operated V-V ECMO. The patient's oxygen saturation improved, and their vital signs gradually stabilized.

In the following days, the Renji Rheumatology and Emergency Intensive Care Team worked together to carry out CRRT renal replacement therapy, monitor input and output volume, cardiac output index, blood gas, coagulation indicators, and adjust treatment plans in a timely manner... After 8 days and nights of effort, ECMO, ventilators, and CRRT were gradually withdrawn, and the patient gradually improved. Currently, they have been transferred to the general ward of the Rheumatology Department for further treatment.

After the first aid line was connected, the patient's hope was reignited

Critical care is the last line of defense to protect the patient's life, and is particularly important for rheumatic patients with multiple organ involvement. Taking systemic lupus erythematosus as an example, patients may experience life-threatening organ dysfunction due to disease activity or immunosuppressive therapy, accounting for 1% to 30% of the total incidence of systemic lupus erythematosus. Severe cases require admission to intensive care units, with a higher mortality rate.

Strive for every minute of life for critically ill patients. The emergency department of Renji Hospital's South Campus has taken the lead in establishing an emergency rheumatism green channel, achieving rapid transportation and enabling patients to receive timely and efficient treatment from the rheumatism department team as soon as they seek medical attention. Last year, this lifeline for rescue was once again upgraded. Under the planning and coordination of the director of the Rheumatology Department, Ye Shuang, the Rheumatology Department established the first rheumatic critical care unit in China, integrating life support technology for multi organ system failure and cutting-edge immune targeted diagnosis and treatment methods.

Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer
Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer

Immunotherapy has been proven to achieve significant therapeutic effects in various solid tumors. However, for pancreatic cancer, known as the "king of cancer", immunotherapy has been ineffective. On August 4, Professor Yu Xianjun, Dean of the Cancer Hospital Affiliated to Fudan University, and Shi Si, Associate Professor of Pancreatic Surgery released a research achievement, which first found the key role of cysteine rich protein 1 in shaping the immunosuppressive microenvironment of pancreatic cancer, filled the gap in the research field of immunosuppressive microenvironment of pancreatic cancer, and provided a theoretical basis for precise immunotherapy of pancreatic cancer patients. Ductal adenocarcinoma of the pancreas is the main type of pancreatic cancer, accounting for about 90% of all pancreatic cancer. Due to its high malignancy and poor treatment effectiveness, pancreatic ductal adenocarcinoma has always been one of the most malignant tumors. In recent years, the level of surgical techniques and comprehensive treatment has been achieved

A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare
A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare

A 14-year-old girl has been experiencing symptoms such as protruding pupils, incomplete eye closure, corneal injury, restricted eye movement, and overall fatigue for several years. The physical discomfort and facial abnormalities caused by eye diseases have made her increasingly reticent, and her temperament is vastly different from before. At the Ophthalmology Department of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the pupil has been diagnosed with a rare thyroid ophthalmopathy combined with myasthenia gravis, which requires prompt treatment. However, considering the young age of the pupil, conventional hormone and radiation therapy cannot be used. Therefore, Zhou Huifang, Deputy Director of Ophthalmology and thyroid ophthalmology expert, has developed a targeted drug combined with surgical treatment plan for it, and targeted drug treatment will be performed first. Three months ago, I was hospitalized for one week with mydriasis and received intravenous targeted drug treatment. Afterwards, I went home for observation and followed up on time

The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease
The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease

According to the Statistics of Chinese Dry Eye Expert Consensus, the incidence rate of dry eye in China is about 21%~30%, and it is estimated that there are at least 300 million patients nationwide. The Dry Eye Diagnosis and Treatment Studio of Shanghai Eye Disease Prevention and Treatment Center was officially launched today. In the future, the studio will continuously improve the dry eye diagnosis and treatment standards, and form standardized diagnosis and treatment concepts and service models. Suitable technologies will be promoted to the community, allowing residents to enjoy convenient dry eye diagnosis and treatment services at their doorstep. Executive Dean and Party Secretary Gao Wei stated that this is also one of the livelihood service measures recently launched by the hospital around high-quality development and meeting the needs of the people. It is reported that dry eye syndrome is a chronic ocular surface disease caused by multiple factors. The instability of the tear film or imbalance of the ocular surface microenvironment caused by abnormal quality, quantity, and dynamics of tears can be accompanied by ocular surface inflammatory reactions, tissue damage, and nerve abnormalities, resulting in various discomforts in the eyes

The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice
The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice

The International Dental Implant Consensus Report, jointly written by the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine and renowned universities in the field of dentistry such as Harvard University, University of Zurich, University of Gothenburg, Columbia University, and University of Frankfurt, has recently been jointly published in top journals in the field of dentistry, including Clinical Periodontology and Clinical Dental Implant Research. This consensus has for the first time established an internationally unified core set of indicators for evaluating the clinical effectiveness of dental implants, covering the five key areas of the field of dental implants. It is of milestone significance for carrying out standardized clinical diagnosis, treatment, and research on dental implants. The core evaluation indicators determined by this consensus will become an important benchmark for scholars in the field of dental implants worldwide to conduct high-quality research. The consensus is composed of 8 top international experts in the field of oral implantation

Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases
Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases

Recently, Catherine, a British girl born in the 1990s, received autologous peripheral blood hematopoietic stem cell transfusion at the Cancer Center of Shanghai Jiahui International Hospital, and was successfully discharged from the warehouse. She is now on her way back to China after being discharged from the hospital. She is also the first patient at Shanghai Jiahui International Hospital to complete relevant treatments. In 2019, Catherine was diagnosed with Hodgkin's lymphoma in the UK, and after treatment, the disease completely improved. During her work and life in China in 2021, she went to seek medical attention due to multiple enlarged lymph nodes. Pathological biopsy confirmed a recurrence of Hodgkin's lymphoma, and through combined targeted drug treatment, her condition was temporarily under control. Last year in the second half of the year, when the disease recurred, the girl began to use immunotherapy combined with targeted drugs for treatment. Expert evaluation suggests that for young patients with hematological tumors, the risk of recurrence is high and treatment difficulty is increasing in the future. Autologous hematopoietic stem cell therapy is recommended