The incidence rate of acute hepatitis B B has dropped to the lowest level in history. World Hepatitis Day | Shanghai has entered the stage of "eliminating hepatitis hazards" Virus | hepatitis | hazards

Release time:Apr 14, 2024 11:23 AM

July 28th is the 13th World Hepatitis Day worldwide. From the 23rd to the 30th, the theme publicity week activity of "adhering to early prevention, strengthening detection, and standardizing antiviral treatment" hosted by the Municipal Health Commission and the ninth "love liver public welfare" expert free clinic activity spread news: Shanghai has entered the stage of "elimination of hepatitis hazards", the incidence rate of acute hepatitis B has dropped to the lowest level in history, and 219 medical institutions in the city can provide hepatitis diagnosis and treatment services.

For many years, Shanghai has attached great importance to the prevention and treatment of viral hepatitis, and measures such as blood safety, immune prevention, testing and treatment, community management, and public education have been effectively implemented. At present, the coverage rate of hepatitis A and hepatitis B vaccines in children's immunization program remains above 99%; Since 2010, based on the principle of "voluntariness and free", hepatitis B vaccination service has been extended to permanent residents over 18 years old in the city. The incidence rate of acute hepatitis B reported in the city has dropped to the lowest level in history, and the carrying rate of hepatitis B surface antigen in children under 5 years old is controlled below 1%.

The first-line drugs for hepatitis B treatment have been included in the city's centralized procurement catalogue, with prices falling sharply and the burden of disease of patients further reduced. Except for 219 medical institutions that can provide hepatitis diagnosis and treatment services, the city has established 30 designated medical institutions for hepatitis C, further improving the city's hepatitis diagnosis and treatment management service system. In order to further eliminate the harm of hepatitis C, according to the national deployment, 30 medical institutions have been selected as the hepatitis C inflammation diagnosis and treatment management service system. Designated medical institutions for hepatitis C can provide laboratory testing, standardized diagnosis and treatment, and follow-up services related to hepatitis C and other hepatitis diseases to the public. In conjunction with the dual channel pharmacy function of medical insurance, it greatly improves the accessibility of hepatitis C drugs to the public. Our city is also actively exploring the establishment of a hepatitis C and other specialized disease management service model consisting of disease prevention and control centers, designated hospitals, and community health service centers. Priority will be given to providing outpatient mutual assistance services for elderly hepatitis patients who have signed contracts with the community, and the quality of treatment services will be continuously improved.

It is worth mentioning that the experience of community management for chronic hepatitis in Shanghai has been adopted by the World Health Organization as a case of eliminating viral hepatitis in China. The contracted management services for chronic hepatitis patients in this city have been expanded to 203 communities in 16 districts, of which 13 districts have achieved full coverage within the service provision areas. More than 90% of community health service centers can provide antiviral treatment drugs for chronic hepatitis patients, and provide contracted management services for nearly 8500 households of chronic hepatitis patients.

Since the implementation of the community health management project for chronic hepatitis patients, the quality of life of the contracted patients has significantly improved, and the burden of family disease has significantly decreased. The antiviral drug treatment rate of the contracted patients has reached nearly 65%, higher than the national average. The proportion of patients with disease fluctuations or acute attacks during the visit period has declined. The proportion of hospitalized patients has declined from 22% at the beginning of the project implementation to 15%, and the proportion of patients with abnormal liver function has declined from 32% to 10%. It has cumulatively provided 77000 doses of adult hepatitis B vaccine for people at high risk of hepatitis B infection for free.

However, the disease burden of chronic hepatitis in our country remains heavy. Most patients with chronic hepatitis are not aware of their own infection status. In April this year, the Shanghai Municipal Health Commission and 10 other departments jointly released the Shanghai Action Plan for Eliminating the Public Health Hazards of Hepatitis C, marking that the city's hepatitis prevention and control work has entered the stage of "group centered risk elimination" from "individual centered treatment and cure".

Intensify testing efforts and promote the detection of hepatitis C infected individuals. At present, our city has included hepatitis C antibody and nucleic acid testing in the routine testing items before invasive or invasive treatment in medical institutions. Minhang District, Pudong New Area, Songjiang District, and Fengxian District have provided hepatitis C related testing services in the free health examination items for elderly people aged 60 and above. The scope of the above tests will be further expanded.

It is reported that at the science popularization and free consultation event held by Yueyang Integrated Traditional Chinese and Western Medicine Hospital affiliated with Shanghai University of Chinese Medicine on the 26th, liver disease experts such as Liu Huabao, a renowned Chinese medicine practitioner from across the country, and Wang Lingtai, a renowned Chinese medicine practitioner from Shanghai, provided health advice to the general public. Zhu Junfeng, Director of the Liver Disease Department at Yueyang Hospital, stated that fatty liver is a progressive disease that, if not controlled, can also develop into fatty liver, cirrhosis, and even liver cancer. Even if mild fatty liver is detected during a citizen's physical examination, it is necessary to seek medical intervention in a timely manner, scientifically and effectively treat and control the progression of the disease, and even achieve a cure.

Expert introduction: patients with fatty liver can accept oral Chinese medicine treatment in the department of liver disease, and can also be combined with acupuncture and moxibustion catgut embedding, external application of penetrating medicine, infrared and ear points to form a "five in one" treatment, which can significantly improve the symptoms of fatigue, liver discomfort, abdominal distension, dull complexion, irregular menstruation, irritability, insomnia, dry mouth, bitter breath and bad breath caused by fatty liver, and reduce high transaminase, high blood fat, high uric acid, high blood sugar, etc. On the day of the free consultation, citizens who came to participate in the event were provided with liver elasticity ultrasound testing, traditional Chinese medicine specialty thread embedding for weight loss and fat reduction, and liver protection tea drinks such as Sanhua tea, Siye Sangen tea, and lipid-lowering Qingbu tea, helping citizens achieve happiness and health.

Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer

Immunotherapy has been proven to achieve significant therapeutic effects in various solid tumors. However, for pancreatic cancer, known as the "king of cancer", immunotherapy has been ineffective. On August 4, Professor Yu Xianjun, Dean of the Cancer Hospital Affiliated to Fudan University, and Shi Si, Associate Professor of Pancreatic Surgery released a research achievement, which first found the key role of cysteine rich protein 1 in shaping the immunosuppressive microenvironment of pancreatic cancer, filled the gap in the research field of immunosuppressive microenvironment of pancreatic cancer, and provided a theoretical basis for precise immunotherapy of pancreatic cancer patients. Ductal adenocarcinoma of the pancreas is the main type of pancreatic cancer, accounting for about 90% of all pancreatic cancer. Due to its high malignancy and poor treatment effectiveness, pancreatic ductal adenocarcinoma has always been one of the most malignant tumors. In recent years, the level of surgical techniques and comprehensive treatment has been achieved

A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare

A 14-year-old girl has been experiencing symptoms such as protruding pupils, incomplete eye closure, corneal injury, restricted eye movement, and overall fatigue for several years. The physical discomfort and facial abnormalities caused by eye diseases have made her increasingly reticent, and her temperament is vastly different from before. At the Ophthalmology Department of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the pupil has been diagnosed with a rare thyroid ophthalmopathy combined with myasthenia gravis, which requires prompt treatment. However, considering the young age of the pupil, conventional hormone and radiation therapy cannot be used. Therefore, Zhou Huifang, Deputy Director of Ophthalmology and thyroid ophthalmology expert, has developed a targeted drug combined with surgical treatment plan for it, and targeted drug treatment will be performed first. Three months ago, I was hospitalized for one week with mydriasis and received intravenous targeted drug treatment. Afterwards, I went home for observation and followed up on time

The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease

According to the Statistics of Chinese Dry Eye Expert Consensus, the incidence rate of dry eye in China is about 21%~30%, and it is estimated that there are at least 300 million patients nationwide. The Dry Eye Diagnosis and Treatment Studio of Shanghai Eye Disease Prevention and Treatment Center was officially launched today. In the future, the studio will continuously improve the dry eye diagnosis and treatment standards, and form standardized diagnosis and treatment concepts and service models. Suitable technologies will be promoted to the community, allowing residents to enjoy convenient dry eye diagnosis and treatment services at their doorstep. Executive Dean and Party Secretary Gao Wei stated that this is also one of the livelihood service measures recently launched by the hospital around high-quality development and meeting the needs of the people. It is reported that dry eye syndrome is a chronic ocular surface disease caused by multiple factors. The instability of the tear film or imbalance of the ocular surface microenvironment caused by abnormal quality, quantity, and dynamics of tears can be accompanied by ocular surface inflammatory reactions, tissue damage, and nerve abnormalities, resulting in various discomforts in the eyes

The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice

The International Dental Implant Consensus Report, jointly written by the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine and renowned universities in the field of dentistry such as Harvard University, University of Zurich, University of Gothenburg, Columbia University, and University of Frankfurt, has recently been jointly published in top journals in the field of dentistry, including Clinical Periodontology and Clinical Dental Implant Research. This consensus has for the first time established an internationally unified core set of indicators for evaluating the clinical effectiveness of dental implants, covering the five key areas of the field of dental implants. It is of milestone significance for carrying out standardized clinical diagnosis, treatment, and research on dental implants. The core evaluation indicators determined by this consensus will become an important benchmark for scholars in the field of dental implants worldwide to conduct high-quality research. The consensus is composed of 8 top international experts in the field of oral implantation

Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases

Recently, Catherine, a British girl born in the 1990s, received autologous peripheral blood hematopoietic stem cell transfusion at the Cancer Center of Shanghai Jiahui International Hospital, and was successfully discharged from the warehouse. She is now on her way back to China after being discharged from the hospital. She is also the first patient at Shanghai Jiahui International Hospital to complete relevant treatments. In 2019, Catherine was diagnosed with Hodgkin's lymphoma in the UK, and after treatment, the disease completely improved. During her work and life in China in 2021, she went to seek medical attention due to multiple enlarged lymph nodes. Pathological biopsy confirmed a recurrence of Hodgkin's lymphoma, and through combined targeted drug treatment, her condition was temporarily under control. Last year in the second half of the year, when the disease recurred, the girl began to use immunotherapy combined with targeted drugs for treatment. Expert evaluation suggests that for young patients with hematological tumors, the risk of recurrence is high and treatment difficulty is increasing in the future. Autologous hematopoietic stem cell therapy is recommended

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