Do children need to pay off their "immunization debt" after the epidemic? Expert advice on how to reduce respiratory infections in children after the start of school | Immunomodulators | Epidemic

Release time:Apr 15, 2024 12:15 PM

As school is about to start and autumn is approaching, children are entering a season of high incidence of respiratory diseases. During the COVID-19, people wearing masks "stayed at home" and had significantly less contact with the outside world, leading to the global phenomenon of "incomplete" immune function of people. Once the external environment is exposed and exposed more, the risk of disease in the population will increase, and foreign experts refer to this phenomenon as "immune debt". How to prepare for the high incidence season of diseases in advance? Recently, Professor Hong Jianguo from the Department of Pediatrics at the First Affiliated People's Hospital of Shanghai Jiao Tong University School of Medicine provided guidance on disease prevention for parents.

A balanced diet does not require excessive supplementation of trace elements

Clinically, it has been found that many children with recurrent respiratory infections have a preference for food. Some consume too much protein, while others do not eat vegetables or eat too little. How to achieve dietary balance? Hong Jianguo introduced that the basic nutritional needs of humans are protein, fat, and carbohydrates. Children's growth requires high-quality protein, which generally comes from eggs, eggs, milk, red meat, and white meat. Some people only eat white meat, and their bodies may lack iron; Some people only eat red meat, which may put a heavier burden on their bodies, so nutritional balance is very important. In addition, various vegetables are rich in vitamins and trace elements, which are also essential.

For children who are picky eaters, vitamins can be supplemented, but both vitamins and trace elements are limited, and excessive consumption can have the opposite effect. Expert example: Some children supplement too much vitamin D, and formula milk powder already contains vitamins and calcium supplements. Adding calcium supplements and vitamins will exceed the limit. For example, zinc. The proportion of children lacking zinc in Shanghai is very low. Unless all drinking water at home is strictly filtered, the probability of children lacking zinc is very low. Therefore, there is no need to supplement zinc specifically in daily life.

Experts also remind that preventing respiratory infections requires developing good hygiene habits, paying attention to hand hygiene, maintaining fresh indoor air, and avoiding crowded areas during disease outbreaks.

Multiple channels to help acquire more immunity

From an immunological perspective, children can only reach adult immunity levels around the age of 7, so early school-age children are more susceptible. Children with recurrent respiratory infections need to achieve immune function repair, which can be supported by traditional Chinese medicine or supplemented by Western medicine. At present, auxiliary drugs on the market, such as bacterial lysates, can also help children enhance their immunity to a certain extent.

Hong Jianguo said that the so-called bacterial solute is a composite preparation composed of several common bacteria dissolved. The basic mechanism of immune preparations is similar to that of specific immune mechanisms, and their specificity is weak, which means they are not as precise as vaccines. However, due to the relatively large molecular weight of immune preparations, their range of action may be wider. For children with recurrent respiratory infections, it is recommended to take bacterial immune modulators before the high incidence season each year. For severe cases, two courses of treatment can be taken in the first year, and then supplemented one month before the high incidence season each year to restore immune function to a relatively complete state.

Specific immunity is equally essential. Clinical data shows that the proportion of severe cases of influenza superimposed by COVID-19 will increase. Children are advised to inject influenza vaccine in the gradual influenza season after school starts. Experts explain that there is a global consensus that vaccination can significantly reduce the risk of contracting influenza and severe influenza. At present, there are two options for influenza vaccines: trivalent and quadrivalent. It is recommended to receive timely vaccination before the flu season each year.

Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer
Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer

Immunotherapy has been proven to achieve significant therapeutic effects in various solid tumors. However, for pancreatic cancer, known as the "king of cancer", immunotherapy has been ineffective. On August 4, Professor Yu Xianjun, Dean of the Cancer Hospital Affiliated to Fudan University, and Shi Si, Associate Professor of Pancreatic Surgery released a research achievement, which first found the key role of cysteine rich protein 1 in shaping the immunosuppressive microenvironment of pancreatic cancer, filled the gap in the research field of immunosuppressive microenvironment of pancreatic cancer, and provided a theoretical basis for precise immunotherapy of pancreatic cancer patients. Ductal adenocarcinoma of the pancreas is the main type of pancreatic cancer, accounting for about 90% of all pancreatic cancer. Due to its high malignancy and poor treatment effectiveness, pancreatic ductal adenocarcinoma has always been one of the most malignant tumors. In recent years, the level of surgical techniques and comprehensive treatment has been achieved

A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare
A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare

A 14-year-old girl has been experiencing symptoms such as protruding pupils, incomplete eye closure, corneal injury, restricted eye movement, and overall fatigue for several years. The physical discomfort and facial abnormalities caused by eye diseases have made her increasingly reticent, and her temperament is vastly different from before. At the Ophthalmology Department of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the pupil has been diagnosed with a rare thyroid ophthalmopathy combined with myasthenia gravis, which requires prompt treatment. However, considering the young age of the pupil, conventional hormone and radiation therapy cannot be used. Therefore, Zhou Huifang, Deputy Director of Ophthalmology and thyroid ophthalmology expert, has developed a targeted drug combined with surgical treatment plan for it, and targeted drug treatment will be performed first. Three months ago, I was hospitalized for one week with mydriasis and received intravenous targeted drug treatment. Afterwards, I went home for observation and followed up on time

The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease
The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease

According to the Statistics of Chinese Dry Eye Expert Consensus, the incidence rate of dry eye in China is about 21%~30%, and it is estimated that there are at least 300 million patients nationwide. The Dry Eye Diagnosis and Treatment Studio of Shanghai Eye Disease Prevention and Treatment Center was officially launched today. In the future, the studio will continuously improve the dry eye diagnosis and treatment standards, and form standardized diagnosis and treatment concepts and service models. Suitable technologies will be promoted to the community, allowing residents to enjoy convenient dry eye diagnosis and treatment services at their doorstep. Executive Dean and Party Secretary Gao Wei stated that this is also one of the livelihood service measures recently launched by the hospital around high-quality development and meeting the needs of the people. It is reported that dry eye syndrome is a chronic ocular surface disease caused by multiple factors. The instability of the tear film or imbalance of the ocular surface microenvironment caused by abnormal quality, quantity, and dynamics of tears can be accompanied by ocular surface inflammatory reactions, tissue damage, and nerve abnormalities, resulting in various discomforts in the eyes

The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice
The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice

The International Dental Implant Consensus Report, jointly written by the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine and renowned universities in the field of dentistry such as Harvard University, University of Zurich, University of Gothenburg, Columbia University, and University of Frankfurt, has recently been jointly published in top journals in the field of dentistry, including Clinical Periodontology and Clinical Dental Implant Research. This consensus has for the first time established an internationally unified core set of indicators for evaluating the clinical effectiveness of dental implants, covering the five key areas of the field of dental implants. It is of milestone significance for carrying out standardized clinical diagnosis, treatment, and research on dental implants. The core evaluation indicators determined by this consensus will become an important benchmark for scholars in the field of dental implants worldwide to conduct high-quality research. The consensus is composed of 8 top international experts in the field of oral implantation

Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases
Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases

Recently, Catherine, a British girl born in the 1990s, received autologous peripheral blood hematopoietic stem cell transfusion at the Cancer Center of Shanghai Jiahui International Hospital, and was successfully discharged from the warehouse. She is now on her way back to China after being discharged from the hospital. She is also the first patient at Shanghai Jiahui International Hospital to complete relevant treatments. In 2019, Catherine was diagnosed with Hodgkin's lymphoma in the UK, and after treatment, the disease completely improved. During her work and life in China in 2021, she went to seek medical attention due to multiple enlarged lymph nodes. Pathological biopsy confirmed a recurrence of Hodgkin's lymphoma, and through combined targeted drug treatment, her condition was temporarily under control. Last year in the second half of the year, when the disease recurred, the girl began to use immunotherapy combined with targeted drugs for treatment. Expert evaluation suggests that for young patients with hematological tumors, the risk of recurrence is high and treatment difficulty is increasing in the future. Autologous hematopoietic stem cell therapy is recommended