Aspartame is officially classified as a "carcinogen": Why do sugar substitutes cause cancer? What other diseases are related to it? Reason | Substitutes | Carcinogens

Release time:Apr 14, 2024 05:27 AM

The official website of the World Health Organization announced today that the Joint Expert Committee on Food Additives of the International Agency for Research on Cancer, the World Health Organization, and the Food and Agriculture Organization has released an assessment report on the health effects of the sugar free sweetener aspartame. The International Agency for Research on Cancer has cited "limited evidence" of human carcinogenicity and classified aspartame as potentially carcinogenic to humans. The Joint Expert Committee reiterated that its daily allowable intake is 40 milligrams per kilogram of body weight. For example, assuming there is no other aspect of food intake, if a beverage contains 200 or 300 milligrams of aspartame, an adult weighing 70 kilograms needs to drink 9 to 14 cans or more per day to exceed the daily allowance.

In recent years, there has been ongoing discussion on whether a series of "sugar substitutes" such as aspartame are harmful to health. Can you still have a pleasant drink after finishing the sentence today? Jiefang Daily's Shangguan News reporter invited Xu Renying, Director of the Nutrition Department of Renji Hospital affiliated with Shanghai Jiao Tong University School of Medicine, to provide an answer.

It is reported that aspartame is an artificial sweetener that has been widely used in various food and beverage products since the 1980s. "It is most commonly found in soft drinks, ice cream, chewing gum, and other foods. In addition, some products such as breakfast cereal, weight loss drinks, toothpaste, cough suppressants, and vitamin chewable tablets also contain aspartame. Consumers can check whether the product has added aspartame through the food label, but the specific amount may not be indicated on the food label." Xu Renying specifically mentioned that although 40 milligrams per kilogram is currently a safe dose for daily consumption, the safety of long-term use is still difficult to evaluate.

In 2022, a French research team released an epidemiological survey based on 102865 participants in China at PLOS Medicine, which showed that artificial sweeteners can increase the risk of tumor development, with aspartame and potassium acetylsulfonate having the most significant effects.

So, why may aspartame be carcinogenic? Xu Renying explained that the main mechanism of its action is that metabolites may cause DNA damage to the body, promote the expression of some tumor genes, and weaken the normal mechanism of clearing cancerous cells in the body, which may jointly lead to the occurrence of tumors. "Cancer is one of the leading causes of death worldwide, with one in every six people dying from cancer." As Dr. Francesco Branca, Director of the Nutrition and Food Safety Division of the World Health Organization, said, the academic community is currently expanding scientific exploration to assess potential triggers or promoters of cancer, in order to reduce both disease and mortality rates.

Xu Renying said that in existing animal experiments, it has been shown that aspartame intake is associated with lymphoma, leukemia, and urinary system tumors. Of course, for epidemiological research, the biggest challenge lies in estimating intake. "The food frequency method and 24-hour dietary review method currently used all have issues with recall bias. Secondly, due to differences in population and tumor types, there may also be differences in research results." Therefore, he proposed his own viewpoint: the relationship between aspartame and tumor development is relatively weak, but there are significant differences. "Aspartame is a possible risk factor for tumor development, but not all carcinogenic factors."

However, in addition to aspartame, artificial sweeteners such as acesulfame and sucralose are also widely used. "It should be said that all artificial sweeteners may have the risk of cancer. The main reason why aspartame has attracted attention this time is that it is the most widely used and the general population has the highest awareness." Xu Renying said that in addition to the potential carcinogenic hazards, it is also closely related to obesity, diabetes, cardiovascular diseases, neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.

It can be said that many consumers choose sugar substitutes for the sake of "health and low sugar". "The main reason why milk tea and beverages cause weight gain is through sugar substitutes and added sugar." Xu Renying explained that this refers not to the sugar contained in the food itself, but to the addition of glucose, sucrose or syrup for taste and other reasons. "If you want to lose weight, you should also limit the sugar content of the food itself in your daily diet to avoid excessive intake and energy surplus. Ultimately, excess sugar can be converted into fat storage, leading to obesity."

The International Agency for Research on Cancer and WHO will continue to monitor new evidence in the future and encourage independent research teams to further study the potential link between aspartame exposure and consumer health effects.

Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer
Why is "Cancer King" immunotherapy ineffective? Fudan Cancer Hospital Reveals New Mechanisms of Immunosuppressive Environment for pancreatic cancer CRIP1 | Tumor | pancreatic cancer

Immunotherapy has been proven to achieve significant therapeutic effects in various solid tumors. However, for pancreatic cancer, known as the "king of cancer", immunotherapy has been ineffective. On August 4, Professor Yu Xianjun, Dean of the Cancer Hospital Affiliated to Fudan University, and Shi Si, Associate Professor of Pancreatic Surgery released a research achievement, which first found the key role of cysteine rich protein 1 in shaping the immunosuppressive microenvironment of pancreatic cancer, filled the gap in the research field of immunosuppressive microenvironment of pancreatic cancer, and provided a theoretical basis for precise immunotherapy of pancreatic cancer patients. Ductal adenocarcinoma of the pancreas is the main type of pancreatic cancer, accounting for about 90% of all pancreatic cancer. Due to its high malignancy and poor treatment effectiveness, pancreatic ductal adenocarcinoma has always been one of the most malignant tumors. In recent years, the level of surgical techniques and comprehensive treatment has been achieved

A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare
A 14-year-old girl suffers from a rare eye disease and receives support from a public welfare fund. Symptoms of "I haven't looked in the mirror for a long time" | Patient | Public welfare

A 14-year-old girl has been experiencing symptoms such as protruding pupils, incomplete eye closure, corneal injury, restricted eye movement, and overall fatigue for several years. The physical discomfort and facial abnormalities caused by eye diseases have made her increasingly reticent, and her temperament is vastly different from before. At the Ophthalmology Department of the Ninth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, the pupil has been diagnosed with a rare thyroid ophthalmopathy combined with myasthenia gravis, which requires prompt treatment. However, considering the young age of the pupil, conventional hormone and radiation therapy cannot be used. Therefore, Zhou Huifang, Deputy Director of Ophthalmology and thyroid ophthalmology expert, has developed a targeted drug combined with surgical treatment plan for it, and targeted drug treatment will be performed first. Three months ago, I was hospitalized for one week with mydriasis and received intravenous targeted drug treatment. Afterwards, I went home for observation and followed up on time

The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease
The municipal eye disease prevention and treatment center launched the dry eye diagnosis and treatment studio, and the incidence rate of dry eye in China is about 21% to 30% of the meibomian gland | dry eye | eye disease

According to the Statistics of Chinese Dry Eye Expert Consensus, the incidence rate of dry eye in China is about 21%~30%, and it is estimated that there are at least 300 million patients nationwide. The Dry Eye Diagnosis and Treatment Studio of Shanghai Eye Disease Prevention and Treatment Center was officially launched today. In the future, the studio will continuously improve the dry eye diagnosis and treatment standards, and form standardized diagnosis and treatment concepts and service models. Suitable technologies will be promoted to the community, allowing residents to enjoy convenient dry eye diagnosis and treatment services at their doorstep. Executive Dean and Party Secretary Gao Wei stated that this is also one of the livelihood service measures recently launched by the hospital around high-quality development and meeting the needs of the people. It is reported that dry eye syndrome is a chronic ocular surface disease caused by multiple factors. The instability of the tear film or imbalance of the ocular surface microenvironment caused by abnormal quality, quantity, and dynamics of tears can be accompanied by ocular surface inflammatory reactions, tissue damage, and nerve abnormalities, resulting in various discomforts in the eyes

The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice
The Ninth Hospital has taken the lead in formulating the world's first consensus on core indicators for clinical evaluation of dental implants, which has been officially published in clinical practice

The International Dental Implant Consensus Report, jointly written by the Ninth People's Hospital affiliated with Shanghai Jiao Tong University School of Medicine and renowned universities in the field of dentistry such as Harvard University, University of Zurich, University of Gothenburg, Columbia University, and University of Frankfurt, has recently been jointly published in top journals in the field of dentistry, including Clinical Periodontology and Clinical Dental Implant Research. This consensus has for the first time established an internationally unified core set of indicators for evaluating the clinical effectiveness of dental implants, covering the five key areas of the field of dental implants. It is of milestone significance for carrying out standardized clinical diagnosis, treatment, and research on dental implants. The core evaluation indicators determined by this consensus will become an important benchmark for scholars in the field of dental implants worldwide to conduct high-quality research. The consensus is composed of 8 top international experts in the field of oral implantation

Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases
Recently, autologous hematopoietic stem cell therapy was completed in Shanghai, and British girls born in the 1990s have suffered from multiple relapses of blood diseases, including stem cells, peripheral blood, and diseases

Recently, Catherine, a British girl born in the 1990s, received autologous peripheral blood hematopoietic stem cell transfusion at the Cancer Center of Shanghai Jiahui International Hospital, and was successfully discharged from the warehouse. She is now on her way back to China after being discharged from the hospital. She is also the first patient at Shanghai Jiahui International Hospital to complete relevant treatments. In 2019, Catherine was diagnosed with Hodgkin's lymphoma in the UK, and after treatment, the disease completely improved. During her work and life in China in 2021, she went to seek medical attention due to multiple enlarged lymph nodes. Pathological biopsy confirmed a recurrence of Hodgkin's lymphoma, and through combined targeted drug treatment, her condition was temporarily under control. Last year in the second half of the year, when the disease recurred, the girl began to use immunotherapy combined with targeted drugs for treatment. Expert evaluation suggests that for young patients with hematological tumors, the risk of recurrence is high and treatment difficulty is increasing in the future. Autologous hematopoietic stem cell therapy is recommended